Gastrointestinal epithelial barrier disorders

Gene: RET

Amber List (moderate evidence)

RET (ret proto-oncogene)
EnsemblGeneIds (GRCh38): ENSG00000165731
EnsemblGeneIds (GRCh37): ENSG00000165731
OMIM: 164761, Gene2Phenotype
RET is in 31 panels

1 review

Olivia Niblock (Genomics England Curator)

Comment on list classification: The evidence suggests that variants in this gene can provide a susceptability to Hirschsprung Disease, but no direct link.
Created: 26 Jul 2018, 1:09 p.m.

History Filter Activity

26 Jul 2018, Gel status: 2

Entity classified by Genomics England curator

Olivia Niblock (Genomics England Curator)

Gene: ret has been classified as Amber List (Moderate Evidence).

25 Jul 2018, Gel status: 2

Panel promoted to version 1.0

Olivia Niblock (Genomics England Curator)

Panel reviews have been assessed and internal clinical team opinion has been sought on this panel, particularly to rule out incidental findings. Panel has been revised through expert review, internal review and literature research. 25/07/2018

17 Apr 2018, Gel status: 2

Added New Source, Set penetrance

Olivia Niblock (Genomics England Curator)

Emory Genetics Laboratory was added to RET. Panel: Gastrointestinal epithelial barrier disorders Phenotypes for gene RET were set to Inflammatory Bowel Disease (Very Early Onset), Early Onset Inflammatory Bowel Disease

17 Apr 2018, Gel status: 1

Added New Source

Olivia Niblock (Genomics England Curator)

RET was added to Gastrointestinal epithelial barrier disorders panel. Sources: UKGTN

17 Apr 2018, Gel status: 1


Olivia Niblock (Genomics England Curator)

RET was created by Olivia Niblock