RET

ret proto-oncogene
OMIM: 164761, Gene2Phenotype

30 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 30 panels
Red RET in Parathyroid Cancer Level 3: Breast and endocrine Level 2: Tumour syndromes Version 1.5	review	Not set	Sources Expert Review Red UKGTN Phenotypes Pituitary Cancer, Parathyroid and Hypercalcemia
Green RET in Familial Hirschsprung Disease Level 3: Gastrointestinal disorders Level 2: Gastroenterological disorders Version 1.11	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Illumina TruGenome Clinical Sequencing Services UKGTN Radboud University Medical Center, Nijmegen Eligibility statement prior genetic testing Alder Hey - Erasmus MC Phenotypes susceptibility to Hirschsprung disease 1, 142623 {Hirschsprung disease, susceptibility to, 1}, 142623 Hirschsprung Disease, Susceptibility To, 1, 142623 Hirschsprung Disease, Dominant Tags monogenic-polygenic
Green RET in Additional findings health related Version 0.116	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Other Expert Review Green Phenotypes Other cancer predisposition Myltiple endocrine Neoplasia Type 2 Adult and child
Amber RET in Gastrointestinal epithelial barrier disorders Level 3: Gastrointestinal disorders Level 2: Gastroenterological disorders Version 1.76	review	Not set	Sources Expert Review Amber Emory Genetics Laboratory UKGTN Phenotypes Inflammatory Bowel Disease (Very Early Onset) Early Onset Inflammatory Bowel Disease
Green RET in Neuroendocrine cancer pertinent cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.5	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Expert list Phenotypes Neuroendocrine cancer
Green RET in Thyroid cancer pertinent cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.4	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Expert list Phenotypes Multiple endocrine neoplasia 2A and 2B Medullary thyroid cancer Pheochromocytoma
Green RET in Adult solid tumours for rare disease Level 3: Tumour syndromes Level 2: Tumour syndromes Version 1.42	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert list Expert Review Green Phenotypes Multiple Endocrine Neoplasia
Red RET in COVID-19 research Level 2: Viral research Version 1.146	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Red London North GLH GOSH PID v.8.0 NHS GMS North West GLH GOSH PID v.8.0 Expert Review Red London North GLH NHS GMS North West GLH Phenotypes Central hypoventilation syndrome, congenital 209880
Red RET in Familial pulmonary fibrosis Level 3: Interstitial lung disorders Level 2: Respiratory disorders Version 1.32	review	Not set	Sources Expert Review Red Emory Genetics Laboratory Phenotypes Pulmonary Disease
Green RET in Gastrointestinal neuromuscular disorders Level 3: Gastrointestinal disorders Level 2: Gastroenterological disorders Version 1.30	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Green UKGTN Radboud University Medical Center, Nijmegen Illumina TruGenome Clinical Sequencing Services Phenotypes {Hirschsprung disease, susceptibility to, 1} 142623 Tags polygenic
Red RET in Sudden death in young people Level 3: Cardiac arrhythmia Level 2: Cardiovascular disorders Version 1.16	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Other Phenotypes Central hypoventilation syndrome, congenital, 209880 CCHS
Green RET in Childhood solid tumours Level 2: Cancer susceptibility Version 5.9 Latest signed off version: v5.0 (30 Apr 2025)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert List Expert Review Green Expert list Phenotypes Multiple Endocrine Neoplasia MEN2B 162300
Green RET in Familial hyperparathyroidism or hypocalciuric hypercalcaemia Level 2: Endocrinology Version 3.7 Latest signed off version: v3.2 (30 Nov 2022)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Illumina TruGenome Clinical Sequencing Services UKGTN Emory Genetics Laboratory Phenotypes Multiple endocrine neoplasia IIB (162300) Multiple endocrine neoplasia IIA (171400)/MEN3
Green RET in Multiple endocrine tumours Level 3: Breast and endocrine Level 2: Tumour syndromes Version 1.15	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Eligibility statement prior genetic testing Expert list UKGTN Radboud University Medical Center, Nijmegen Illumina TruGenome Clinical Sequencing Services Emory Genetics Laboratory Phenotypes Multiple endocrine neoplasia IIA, 171400 Multiple Endocrine Neoplasia Multiple Endocrine Neoplasia Type 2: RET Gene Deletion/Duplication MEN2-like spectrum Endocrine Cancer
Green RET in Inherited phaeochromocytoma and paraganglioma Level 3: Breast and endocrine Level 2: Tumour syndromes Version 1.12	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Eligibility statement prior genetic testing Radboud University Medical Center, Nijmegen Illumina TruGenome Clinical Sequencing Services UKGTN Emory Genetics Laboratory Phenotypes Multiple Endocrine Neoplasia Multiple endocrine neoplasia IIA, 171400Medullary thyroid carcinoma, 155240Multiple endocrine neoplasia IIB, 162300Central hypoventilation syndrome, congenital, 209880Pheochromocytoma, 171300Renal agenesis, 191830{Hirschsprung disease, susceptibility to, 1}, 142623
Green RET in Inherited phaeochromocytoma and paraganglioma excluding NF1 Level 2: Endocrinology Version 3.10 Latest signed off version: v3.0 (7 Aug 2024)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green NHS GMS Phenotypes Multiple endocrine neoplasia IIA, 171400Medullary thyroid carcinoma, 155240Multiple endocrine neoplasia IIB, 162300Central hypoventilation syndrome, congenital, 209880Pheochromocytoma, 171300Renal agenesis, 191830{Hirschsprung disease, susceptibility to, 1}, 142623 Multiple Endocrine Neoplasia
Green RET in Endocrine neoplasia Level 2: Endocrinology Version 3.4 Latest signed off version: v3.0 (22 Mar 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green NHS GMS Phenotypes MEN2-like spectrum Multiple Endocrine Neoplasia Type 2: RET Gene Deletion/Duplication Multiple endocrine neoplasia IIA, 171400 Endocrine Cancer Multiple Endocrine Neoplasia
Red RET in Primary immunodeficiency or monogenic inflammatory bowel disease Level 2: Immunology Version 8.78 Latest signed off version: v8.0 (30 Apr 2025)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources GOSH PID v.8.0 Expert Review Red London North GLH NHS GMS North West GLH Phenotypes Central hypoventilation syndrome, congenital 209880
Red RET in Unexplained kidney failure in young people Level 3: Disorders of function Level 2: Renal and urinary tract disorders Version 1.124	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Red Expert list Radboud University Medical Center, Nijmegen Illumina TruGenome Clinical Sequencing Services Phenotypes Renal Adysplasia Multiple endocrine neoplasia IIA, 171400 Medullary thyroid carcinoma, 155240 Multiple endocrine neoplasia IIB, 162300 Central hypoventilation syndrome, congenital, 209880 Pheochromocytoma, 171300 Renal agenesis, 191830 {Hirschsprung disease, susceptibility to, 1}, 142623
Green RET in Childhood solid tumours cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.30	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Expert list Phenotypes Multiple Endocrine Neoplasia
Green RET in Adult solid tumours cancer susceptibility Level 2: Cancer susceptibility Version 2.35 Latest signed off version: v2.2 (18 Feb 2020)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert Review Green Expert list Phenotypes Multiple Endocrine Neoplasia
Green RET in CAKUT Level 3: Structural renal and urinary tract disease Level 2: Renal and urinary tract disorders Version 1.181	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Green Expert list Radboud University Medical Center, Nijmegen Illumina TruGenome Clinical Sequencing Services Phenotypes Renal Adysplasia Multiple endocrine neoplasia IIA, 171400 Medullary thyroid carcinoma, 155240 Multiple endocrine neoplasia IIB, 162300 Central hypoventilation syndrome, congenital, 209880 Pheochromocytoma, 171300 Renal agenesis, 191830 {Hirschsprung disease, susceptibility to, 1}, 142623
Green RET in Fetal anomalies Level 2: Fetal (including NIPD) Version 6.140 Latest signed off version: v6.0 (30 Apr 2025)	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Green PAGE DD-Gene2Phenotype Phenotypes RENAL AGENESIS MULTIPLE ENDOCRINE NEOPLASIA IIB
Green RET in DDG2P Version 6.424 Latest signed off version: v6.0 (30 Apr 2025) Component of the following Super Panels: Paediatric disorders	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green DD-Gene2Phenotype Phenotypes RENAL AGENESIS 191830 MULTIPLE ENDOCRINE NEOPLASIA IIB 162300
Red RET in Intellectual disability Level 2: Developmental disorders Version 9.285 Latest signed off version: v9.0 (30 Apr 2025) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Red BRIDGE study SPEED NEURO Tier1 Gene Phenotypes Gene2Phenotype both DD and IF gene with ID HPO
Green RET in Additional findings health related - children Version 1.1 Component of the following Super Panels: Additional findings health related - adults	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Other Expert Review Green Phenotypes Other cancer predisposition Myltiple endocrine Neoplasia Type 2 Adult and child
Green RET in Paediatric pseudo-obstruction syndrome Level 2: Gastrohepatology Version 2.5 Latest signed off version: v2.0 (30 Apr 2025)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Expert list Phenotypes {Hirschsprung disease, susceptibility to, 1}, 142623 {Hirschsprung disease, protection against}, 142623
Green RET in Hirschsprung disease Level 2: Gastrohepatology Version 1.3 Latest signed off version: v1.0 (14 Sep 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green NHS GMS Phenotypes {Hirschsprung disease, protection against}, OMIM:142623 {Hirschsprung disease, susceptibility to, 1}, OMIM:14262 Hirschsprung disease, susceptibility to, 1, MONDO:0007723
Green RET in Multiple endocrine neoplasia type 2 Level 2: Endocrinology Version 1.3 Latest signed off version: v1.0 (14 Sep 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green NHS GMS Phenotypes Multiple endocrine neoplasia IIA, OMIM:171400 Multiple endocrine neoplasia IIB, OMIM:162300 multiple endocrine neoplasia type 2A, MONDO:0008234 multiple endocrine neoplasia type 2B, MONDO:0008082
Green RET in Unexplained young onset end-stage renal disease - additional genes Level 2: Renal Version 1.4 Latest signed off version: v1.1 (30 Apr 2025) Component of the following Super Panels: Unexplained young onset end-stage renal disease	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources NHS GMS Expert Review Green Phenotypes {Hirschsprung disease, susceptibility to, 1}, OMIM:142623 Multiple endocrine neoplasia IIA, OMIM:171400 Multiple endocrine neoplasia IIB, OMIM:162300 Pheochromocytoma, OMIM:171300

RET

30 panels

Red RET in Parathyroid Cancer

Sources

Phenotypes

Green RET in Familial Hirschsprung Disease

Sources

Phenotypes

Tags

Green RET in Additional findings health related

Sources

Phenotypes

Amber RET in Gastrointestinal epithelial barrier disorders

Sources

Phenotypes

Green RET in Neuroendocrine cancer pertinent cancer susceptibility

Sources

Phenotypes

Green RET in Thyroid cancer pertinent cancer susceptibility

Sources

Phenotypes

Green RET in Adult solid tumours for rare disease

Sources

Phenotypes

Red RET in COVID-19 research

Sources

Phenotypes

Red RET in Familial pulmonary fibrosis

Sources

Phenotypes

Green RET in Gastrointestinal neuromuscular disorders

Sources

Phenotypes

Tags

Red RET in Sudden death in young people

Sources

Phenotypes

Green RET in Childhood solid tumours

Sources

Phenotypes

Green RET in Familial hyperparathyroidism or hypocalciuric hypercalcaemia

Sources

Phenotypes

Green RET in Multiple endocrine tumours

Sources

Phenotypes

Green RET in Inherited phaeochromocytoma and paraganglioma

Sources

Phenotypes

Green RET in Inherited phaeochromocytoma and paraganglioma excluding NF1

Sources

Phenotypes

Green RET in Endocrine neoplasia

Sources

Phenotypes

Red RET in Primary immunodeficiency or monogenic inflammatory bowel disease

Sources

Phenotypes

Red RET in Unexplained kidney failure in young people

Sources

Phenotypes

Green RET in Childhood solid tumours cancer susceptibility

Sources

Phenotypes

Green RET in Adult solid tumours cancer susceptibility

Sources

Phenotypes

Green RET in CAKUT

Sources

Phenotypes

Green RET in Fetal anomalies

Sources

Phenotypes

Green RET in DDG2P

Sources

Phenotypes

Red RET in Intellectual disability

Sources

Phenotypes

Green RET in Additional findings health related - children