Additional findings health related

Gene: RET

Green List (high evidence)

RET (ret proto-oncogene)
EnsemblGeneIds (GRCh38): ENSG00000165731
EnsemblGeneIds (GRCh37): ENSG00000165731
OMIM: 164761, Gene2Phenotype
RET is in 28 panels

1 review

Sarah Leigh (Genomics England Curator)

Comment on phenotypes: Clinically relevant transcript NM_020975.4
Created: 21 May 2018, 3:59 p.m.

History Filter Activity

27 Jan 2020, Gel status: 3

Set transcript

Catherine Snow (Genomics England)

Transcript for gene RET was changed from ENST00000355710.8 to ENST00000355710.8; NM_020975.4

20 Nov 2019, Gel status: 3

Set transcript

Ellen McDonagh (Genomics England Curator)

Transcript for gene RET was changed from ENST00000355710.7 to ENST00000355710.8

20 Nov 2019, Gel status: 3

Set Phenotypes, Set transcript

Ellen McDonagh (Genomics England Curator)

Phenotypes for gene: RET were changed from ENST00000355710.7; Other cancer predisposition; Myltiple endocrine Neoplasia Type 2; Adult and child to Other cancer predisposition; Myltiple endocrine Neoplasia Type 2; Adult and child Transcript for gene RET was changed from None to ENST00000355710.7

10 Oct 2019, Gel status: 3

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for gene: RET were changed from NM_020975.4; Other cancer predisposition; Myltiple endocrine Neoplasia Type 2; Adult and child to ENST00000355710.7; Other cancer predisposition; Myltiple endocrine Neoplasia Type 2; Adult and child

30 Sep 2019, Gel status: 3

Removed Source, Removed Source, Added New Source, Set mode of pathogenicity

Ellen McDonagh (Genomics England Curator)

Source Additional Findings was removed from RET. Source ACMG was removed from RET. Source Other was added to RET. Mode of pathogenicity for gene RET was changed from None to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments

21 May 2018, Gel status: 3

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for RET were set to NM_020975.4; Other cancer predisposition; Myltiple endocrine Neoplasia Type 2; Adult and child

3 Apr 2018, Gel status: 3

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for RET were set to Other cancer predisposition; Myltiple endocrine Neoplasia Type 2; Adult and child

3 Apr 2018, Gel status: 3

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

3 Apr 2018, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

RET was added to Genomics England Secondary Findings panel. Sources: ACMG,Additional Findings

3 Apr 2018, Gel status: 1

Created

Ellen McDonagh (Genomics England Curator)

RET was created by Ellen McDonagh