Additional findings health related

Gene: APC

Green List (high evidence)

APC (APC, WNT signaling pathway regulator)
EnsemblGeneIds (GRCh38): ENSG00000134982
EnsemblGeneIds (GRCh37): ENSG00000134982
OMIM: 611731, Gene2Phenotype
APC is in 16 panels

1 review

Sarah Leigh (Genomics England Curator)

Comment on phenotypes: Clinically relevant transcript NM_000038.5
Created: 21 May 2018, 3:49 p.m.

History Filter Activity

27 Jan 2020, Gel status: 3

Set transcript

Catherine Snow (Genomics England)

Transcript for gene APC was changed from ENST00000257430.9 to ENST00000257430.9; NM_000038.5

19 Nov 2019, Gel status: 3

Removed Source, Removed Source, Added New Source, Set Phenotypes, Set transcript

Ellen McDonagh (Genomics England Curator)

Source Additional Findings was removed from APC. Source ACMG was removed from APC. Source Expert list was added to APC. Phenotypes for gene: APC were changed from ENST00000257430.8; Bowel cancer predisposition; Familial Adenomatous Polyposis; Adult and child to Bowel cancer predisposition; Familial Adenomatous Polyposis; Adult and child Transcript for gene APC was changed from None to ENST00000257430.9

10 Oct 2019, Gel status: 3

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for gene: APC were changed from ENST00000257430; Bowel cancer predisposition; Familial Adenomatous Polyposis; Adult and child to ENST00000257430.8; Bowel cancer predisposition; Familial Adenomatous Polyposis; Adult and child

10 Oct 2019, Gel status: 3

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for gene: APC were changed from NM_000038.5; ENST00000257430.8; Bowel cancer predisposition; Familial Adenomatous Polyposis; Adult and child to ENST00000257430; Bowel cancer predisposition; Familial Adenomatous Polyposis; Adult and child

10 Oct 2019, Gel status: 3

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for gene: APC were changed from NM_000038.5; Bowel cancer predisposition; Familial Adenomatous Polyposis; Adult and child to NM_000038.5; ENST00000257430.8; Bowel cancer predisposition; Familial Adenomatous Polyposis; Adult and child

21 May 2018, Gel status: 3

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for APC were set to NM_000038.5; Bowel cancer predisposition; Familial Adenomatous Polyposis; Adult and child

3 Apr 2018, Gel status: 3

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for APC were set to Bowel cancer predisposition; Familial Adenomatous Polyposis; Adult and child

3 Apr 2018, Gel status: 3

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

3 Apr 2018, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

APC was added to Genomics England Secondary Findings panel. Sources: ACMG,Additional Findings

3 Apr 2018, Gel status: 1

Created

Ellen McDonagh (Genomics England Curator)

APC was created by Ellen McDonagh