APC

APC, WNT signaling pathway regulator
OMIM: 611731, Gene2Phenotype

16 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 16 panels
Green APC in Inherited non-medullary thyroid cancer Level 3: Breast and endocrine Level 2: Tumour syndromes Version 1.8	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green UKGTN Radboud University Medical Center, Nijmegen Illumina TruGenome Clinical Sequencing Services Emory Genetics Laboratory Phenotypes Adenomatous polyposis coli (Thyroid papillary carcinoma in patients with APC) 175100
Green APC in Additional findings health related Version 0.116	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert list Expert Review Green Phenotypes Bowel cancer predisposition Familial Adenomatous Polyposis Adult and child
Green APC in Brain cancer pertinent cancer susceptibility Level 2: Cancer susceptibility Version 1.5 Latest signed off version: v1.0 (29 Sep 2021)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Expert list Phenotypes Adult Glioma
Green APC in Colorectal cancer pertinent cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.1	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Expert list Phenotypes Colorectal cancer
Green APC in Familial Tumours Syndromes of the central & peripheral Nervous system Level 3: Muscle and nerve Level 2: Tumour syndromes Version 1.15	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Green Emory Genetics Laboratory Phenotypes Brain, CNS, and PNS Cancer
Green APC in Adult solid tumours for rare disease Level 3: Tumour syndromes Level 2: Tumour syndromes Version 1.42	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert list Expert Review Green Phenotypes Familial Adenomatous Polyposis
Green APC in GI tract tumours Level 3: GI tract Level 2: Tumour syndromes Version 1.27	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources NHS GMS Expert List Illumina TruGenome Clinical Sequencing Services UKGTN Expert Review Green Eligibility statement prior genetic testing Expert list Emory Genetics Laboratory Phenotypes Adenomatous polyposis coli 175100 Brain tumor-polyposis syndrome 2 175100 Gardner syndrome 175100 Desmoid disease, hereditary 135290
Green APC in Childhood solid tumours Level 2: Cancer susceptibility Version 5.9 Latest signed off version: v5.0 (30 Apr 2025)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert List Expert Review Green Expert list Phenotypes Familial Adenomatous Polyposis 175100
Green APC in Inherited polyposis and early onset colorectal cancer - germline testing Level 2: Inherited cancer Version 3.11 Latest signed off version: v3.0 (7 Aug 2024)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green NHS GMS Expert List Phenotypes Desmoid disease, hereditary, OMIM:135290 Brain tumor-polyposis syndrome 2, OMIM:175100 Gardner syndrome, OMIM:175100 Adenomatous polyposis coli, OMIM:175100 Gastric adenocarcinoma and proximal polyposis of the stomach, OMIM:619182
No list APC in Multiple monogenic benign skin tumours Level 2: Dermatology Version 2.5 Latest signed off version: v2.0 (30 Nov 2022)	review	MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted	Sources Expert Review Removed London North GLH NHS GMS Phenotypes Desmoid disease Tags curated_removed
Green APC in Childhood solid tumours cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.30	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Expert list Phenotypes Familial Adenomatous Polyposis
Green APC in Adult solid tumours cancer susceptibility Level 2: Cancer susceptibility Version 2.35 Latest signed off version: v2.2 (18 Feb 2020)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert Review Green Expert list Phenotypes Familial Adenomatous Polyposis
Amber APC in Sarcoma susceptibility Level 2: Cancer susceptibility Version 1.82 Latest signed off version: v1.2 (18 Feb 2020)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert Review Amber Expert list Phenotypes Gardner syndrome, OMIM:175100 Sarcoma, MONDO:0005089
Green APC in Additional findings health related - children Version 1.1 Component of the following Super Panels: Additional findings health related - adults	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Green Expert list Phenotypes Familial Adenomatous Polyposis Adult and child Bowel cancer predisposition
Green APC in Additional findings health related - CNV analysis children Version 1.1 Component of the following Super Panels: Additional findings health related - CNV analysis adults	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert list Expert Review Green Phenotypes Familial Adenomatous Polyposis Adult and child Bowel cancer predisposition
Green APC in APC associated Polyposis Level 2: Inherited cancer Version 1.3 Latest signed off version: v1.0 (14 Sep 2023)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert Review Green Phenotypes Desmoid disease, hereditary, OMIM:135290 Adenomatous polyposis coli, OMIM:175100 Brain tumor-polyposis syndrome 2, OMIM:175100 Gardner syndrome, OMIM:175100 Gastric adenocarcinoma and proximal polyposis of the stomach, OMIM:619182 desmoid tumor, MONDO:0007608 gastric adenocarcinoma and proximal polyposis of the stomach, MONDO:0017790 familial adenomatous polyposis 1, MONDO:0021056