Inherited non-medullary thyroid cancerGene: APC
Comment when marking as ready: At least nine published cases of papillary thyroid cancer in patients with APC variants and Adenomatous polyposis coli
Created: 21 Jun 2017, 1:48 p.m.
I would include in FNMTC panel, although GI penetrance of FAP is much higher so likely that phenotype would be apparent
Created: 13 Jun 2017, 6:13 a.m.
Clear association between APC mutations and papillary thyroid carcinoma
Created: 8 Jun 2017, 5:08 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Adenomatous polyposis; papillary thyroid cancer
Variants in this GENE are reported as part of current diagnostic practice
All genes have been reviewed and the reviews evaluated. 07.08.2017
This gene has been classified as Green List (High Evidence).
Phenotypes for APC were set to Adenomatous polyposis coli (Thyroid papillary carcinoma in patients with APC) 175100
Publications for APC were set to https://doi.org/10.1016/j.mpdhp.2016.02.005; 28490611; 26697262
APC was added to Inherited non-medullary thyroid cancerpanel. Source: UKGTN
APC was added to Inherited non-medullary thyroid cancerpanel. Source: Radboud University Medical Center, Nijmegen
APC was added to Inherited non-medullary thyroid cancerpanel. Source: Illumina TruGenome Clinical Sequencing Services
APC was created by sleigh
APC was added to Inherited non-medullary thyroid cancerpanel. Sources: Emory Genetics Laboratory