Inherited non-medullary thyroid cancer
Gene: WRN
Can be included, although other phenotypic features of Werner would be apparent as their penetrance is much higher than for NTMC in Werner.Created: 13 Jun 2017, 6:30 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Should pick up this diagnosis clinically. Is clear evidence of association with thyroid malignancyCreated: 9 Jun 2017, 8:26 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Werner Syndrome
Publications
Variants in this GENE are reported as part of current diagnostic practice
Comment when marking as ready: Thyroid cancers have been associated with Werner syndrome 277700. WRN associated with Werner syndrome 277700 in OMIM and as a confirmed G2P. At least 10 variants reported.Created: 10 Jul 2017, 12:57 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Werner syndrome 277700
Publications
All genes have been reviewed and the reviews evaluated. 07.08.2017
This gene has been classified as Green List (High Evidence).
Publications for WRN were set to 8722214; 23573208; 8602509
WRN was added to Inherited non-medullary thyroid cancerpanel. Sources: UKGTN,Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,Literature
WRN was created by sleigh