Inherited non-medullary thyroid cancer
Gene: BRCA2
BRCA2 (BRCA2, DNA repair associated)
EnsemblGeneIds (GRCh38): ENSG00000139618
EnsemblGeneIds (GRCh37): ENSG00000139618
OMIM: 600185, Gene2Phenotype
BRCA2 is in 36 panels
EnsemblGeneIds (GRCh38): ENSG00000139618
EnsemblGeneIds (GRCh37): ENSG00000139618
OMIM: 600185, Gene2Phenotype
BRCA2 is in 36 panels
1 review
Sarah Leigh (Genomics England Curator)
One potentially pathogenic found in two members of one family with non-medullary thyroid cancerCreated: 26 Jun 2017, 2:33 p.m.
Mode of inheritance
Unknown
Phenotypes
non-medullary thyroid cancer
Publications
Details
- Mode of Inheritance
- Unknown
- Sources
-
- Literature
- Phenotypes
-
- non-medullary thyroid cancer
- OMIM
- 600185
- Clinvar variants
- Variants in BRCA2
- Penetrance
- Complete
- Publications
- Panels with this gene
-
- Childhood solid tumours
- Inherited non-medullary thyroid cancer
- Additional findings health related
- Inherited ovarian cancer (without breast cancer)
- NICE approved PARP inhibitor treatment
- Monogenic short stature
- Radial dysplasia
- Intellectual disability
- Familial breast cancer
- Ovarian cancer pertinent cancer susceptibility
- Adult solid tumours cancer susceptibility
- Haematological malignancies cancer susceptibility
- Limb disorders
- Severe microcephaly
- Fetal anomalies
- Inherited prostate cancer
- Breast cancer pertinent cancer susceptibility
- Haematological malignancies for rare disease
- Inherited pancreatic cancer
- Primary immunodeficiency or monogenic inflammatory bowel disease
- DDG2P
- Inherited breast cancer and ovarian cancer
- Familial melanoma
- Childhood solid tumours cancer susceptibility
- Pigmentary skin disorders
- Cytopenias and congenital anaemias
- COVID-19 research
- Fanconi anaemia or Bloom syndrome
- Prostate cancer pertinent cancer susceptibility
- Neurofibromatosis Type 1
- Adult solid tumours for rare disease
- Additional findings health related - CNV analysis adult specific
- GI tract tumours
- Sarcoma susceptibility
- Familial prostate cancer
- Additional findings health related - adult specific
History Filter Activity
7 Aug 2017, Gel status: 0
panel promoted to version 1
Sarah Leigh (Genomics England Curator)All genes have been reviewed and the reviews evaluated. 07.08.2017
26 Jun 2017, Gel status: 0
Created
Sarah Leigh (Genomics England Curator)BRCA2 was created by sleigh
26 Jun 2017, Gel status: 0
Added New Source
Sarah Leigh (Genomics England Curator)BRCA2 was added to Inherited non-medullary thyroid cancerpanel. Sources: Literature