Inherited non-medullary thyroid cancer
Gene: TGComment when marking as ready: Associated with phenotype in OMIM, not in G2P. At least one biallelic variant reported in two siblings with recurrent goiters and metastatic follicular thyroid carcinoma in one of these. Parents were monozygous.Created: 10 Jul 2017, 10:41 a.m.
I am not aware of any publications demonstrating the presence of germline thyroglobulin mutations in FNMTC. Couple of SNPs have shown association,
Akdi A, Pérez G, Pastor S, Castell J, Biarnés J, Marcos R, Velázquez A.
Thyroid. 2011 May;21(5):519-25. doi: 10.1089/thy.2010.0384. Epub 2011 Apr 10.
PMID: 21476894
He H, Nagy R, Liyanarachchi S, Jiao H, Li W, Suster S, Kere J, de la Chapelle A.
Cancer Res. 2009 Jan 15;69(2):625-31.
Here, we don't know if the balletic changes were independently responsible for development of ca thyroid, so I wouldn't include.
Raef H, Al-Rijjal R, Al-Shehri S, Zou M, Al-Mana H, Baitei EY, Parhar RS, Al-Mohanna FA, Shi Y.
J Clin Endocrinol Metab. 2010 Mar;95(3):1000-6. doi: 10.1210/jc.2009-1823. Epub 2010 Jan 20.
PMID: 20089614
Created: 13 Jun 2017, 6:24 a.m.
Single case described.Created: 9 Jun 2017, 8:16 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
All genes have been reviewed and the reviews evaluated. 07.08.2017
This gene has been classified as Red List (Low Evidence).
This gene has been classified as Red List (Low Evidence).
Publications for TG were set to 16403815; 21476894; 28345837
TG was added to Inherited non-medullary thyroid cancerpanel. Source: UKGTN
TG was added to Inherited non-medullary thyroid cancerpanel. Source: Radboud University Medical Center, Nijmegen
TG was added to Inherited non-medullary thyroid cancerpanel. Source: Literature
TG was created by sleigh
TG was added to Inherited non-medullary thyroid cancerpanel. Sources: Illumina TruGenome Clinical Sequencing Services