Multiple endocrine tumours

Gene: RET

Green List (high evidence)

RET (ret proto-oncogene)
EnsemblGeneIds (GRCh38): ENSG00000165731
EnsemblGeneIds (GRCh37): ENSG00000165731
OMIM: 164761, Gene2Phenotype
RET is in 28 panels

4 reviews

Katie Snape (South London GMC)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Variants in this GENE are reported as part of current diagnostic practice

Treena Cranston (Oxford)

Green List (high evidence)

Sian Ellard (University of Exeter Medical School)

Green List (high evidence)

Louise IZATT (GSTT Clinical Genetics Service)

Green List (high evidence)

Variants in this gene are already reported as part of UKGTN diagnostic service, but GeL will offer WGS analysis.
Created: 16 Oct 2015, 12:53 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Details

History Filter Activity

1 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

1 Feb 2016, Gel status: 4

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for RET was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

20 Aug 2015, Gel status: 4

Set Phenotypes

Eik Haraldsdottir (Genomics England)

Phenotypes for gene RET were set to Multiple endocrine neoplasia IIA, 171400;Multiple Endocrine Neoplasia;Multiple Endocrine Neoplasia Type 2: RET Gene Deletion/Duplication;MEN2-like spectrum; Endocrine Cancer

12 Aug 2015, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

RET was added to Multiple endocrine tumourspanel. Sources: Eligibility statement prior genetic testing

8 May 2015, Gel status: 4

Added New Source

Eik Haraldsdottir (Genomics England)

RET was added to Multiple endocrine tumourspanel. Sources: Eligibility Statements for GeL,Expert list

8 May 2015, Gel status: 4

Added New Source

Eik Haraldsdottir (Genomics England)

RET was added to Multiple endocrine tumourspanel. Sources: Eligibility Statements for GeL,Expert list

8 May 2015, Gel status: 4

Added New Source

Eik Haraldsdottir (Genomics England)

RET was added to Multiple endocrine tumourspanel. Sources: Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,UKGTN

8 May 2015, Gel status: 3

Added New Source

Eik Haraldsdottir (Genomics England)

RET was added to Multiple endocrine tumourspanel. Sources: Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,UKGTN

8 May 2015, Gel status: 2

Added New Source

Eik Haraldsdottir (Genomics England)

RET was added to Multiple endocrine tumourspanel. Sources: Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,UKGTN

8 May 2015, Gel status: 1

Added New Source

Eik Haraldsdottir (Genomics England)

RET was added to Multiple endocrine tumourspanel. Sources: Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,UKGTN