Multiple endocrine tumours

Gene: SDHD

Green List (high evidence)

SDHD (succinate dehydrogenase complex subunit D)
EnsemblGeneIds (GRCh38): ENSG00000204370
EnsemblGeneIds (GRCh37): ENSG00000204370
OMIM: 602690, Gene2Phenotype
SDHD is in 25 panels

5 reviews

Sian Ellard (University of Exeter Medical School)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)

Variants in this GENE are reported as part of current diagnostic practice

Louise IZATT (GSTT Clinical Genetics Service)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)

Katie Snape (South London GMC)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)

Variants in this GENE are reported as part of current diagnostic practice

Treena Cranston (Oxford)

Green List (high evidence)

Ellen McDonagh (Genomics England Curator)

Comment on mode of inheritance: Indicated by 3 reviewers.
Created: 1 Feb 2016, 12:42 p.m.
Comment on list classification: All four reviewers agree this should be green.
Created: 1 Feb 2016, 12:39 p.m.

History Filter Activity

1 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

1 Feb 2016, Gel status: 4

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for SDHD was changed to MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)

1 Feb 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

20 Aug 2015, Gel status: 2

Set Mode of Inheritance

Eik Haraldsdottir (Genomics England)

Model of inheritance for gene SDHD was set to Unknown

20 Aug 2015, Gel status: 2

Added New Source

Eik Haraldsdottir (Genomics England)

SDHD was added to Multiple endocrine tumourspanel. Source: Radboud University Medical Center, Nijmegen

20 Aug 2015, Gel status: 1

Added New Source

Eik Haraldsdottir (Genomics England)

SDHD was added to Multiple endocrine tumourspanel. Sources: Emory Genetics Laboratory,Radboud University Medical Center, Nijmegen