Multiple endocrine tumours
Gene: MAX
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Variants in this GENE are reported as part of current diagnostic practice
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Variants in this GENE are reported as part of current diagnostic practice
Comment on mode of inheritance: Publication below showed biallelic expression of MAX so not imprinted.Created: 2 Feb 2016, 2:41 p.m.
Comment on mode of inheritance: Mixed mode of inheritance from different reviewers in terms of imprinting status.Created: 1 Feb 2016, 12:49 p.m.
Comment on list classification: 3 reviewers agree, and on the COSMIC cancer consenus gene list.Created: 1 Feb 2016, 12:47 p.m.
Multiple primary NET tumour predisposition- more for PCC and PPLCreated: 16 Oct 2015, 1 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)
Phenotypes for gene: MAX were changed from Endocrine Cancer to {Pheochromocytoma, susceptibility to}, OMIM:171300
Mode of inheritance for MAX was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications for MAX were set to PubMed: 21685915
This gene has been classified as Green List (High Evidence).
Mode of inheritance for MAX was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
This gene has been classified as Green List (High Evidence).
MAX was added to Multiple endocrine tumourspanel. Sources: Emory Genetics Laboratory