Childhood solid tumours
Gene: RETComment on mode of pathogenicity: Updating the mode of pathogenicity in line with the Adult solid tumours cancer susceptibility panel https://panelapp.genomicsengland.co.uk/panels/245/Created: 4 Mar 2020, 10:12 a.m. | Last Modified: 4 Mar 2020, 10:12 a.m.
Panel Version: 2.5
As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that there is enough evidence to rate this gene greenCreated: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Multiple Endocrine Neoplasia
Comment on list classification: MEN2B: Marfanoid habitus and thyroid cancer predisposition in childhoodCreated: 8 Mar 2016, 12:16 a.m.
Mode of pathogenicity for gene: RET was changed from to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments
Source NHS GMS was added to RET. Mode of inheritance for gene RET was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Added phenotypes Multiple Endocrine Neoplasia for gene: RET Publications for gene RET were changed from 17963006 to 23788249
Source Expert List was added to RET. Rating Changed from Green List (high evidence) to Green List (high evidence)
This gene has been classified as Green List (High Evidence).
This gene has been classified as Green List (High Evidence).
RET was created by richardhywel
RET was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Expert list