Childhood solid tumours
Gene: EZH2
As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that there is enough evidence to rate this gene green.Created: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Weaver syndrome, 277590
Comment on list classification: See reviewCreated: 7 Mar 2016, 11:31 p.m.
Malignancy is not common but occurs with increased frequency in childhood in EZHZ-Weaver syndromeCreated: 7 Mar 2016, 11:27 p.m.
Phenotypes
277590
Publications
Comment when marking as ready: Weaver syndrome is similar to Beckwith Wiedemann but not associated with malignancy.Created: 14 Feb 2016, 4:44 p.m.
Source NHS GMS was added to EZH2. Added phenotypes Weaver syndrome, 277590 for gene: EZH2
Source Expert List was added to EZH2. Rating Changed from Green List (high evidence) to Green List (high evidence)
This gene has been classified as Green List (High Evidence).
This gene has been classified as Red List (Low Evidence).
This gene has been classified as Red List (Low Evidence).
EZH2 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: UKGTN
Model of inheritance for gene EZH2 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
EZH2 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Illumina TruGenome Clinical Sequencing Services
EZH2 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Radboud University Medical Center, Nijmegen