Childhood solid tumours
Gene: BRIP1
As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that there is enough evidence to rate this gene green.Created: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Phenotypes
Fanconi Anaemia
Phenotypes for gene: BRIP1 were changed from Fanconi anemia, complementation group J, 609054; Fanconi anemia, complementation group J, 609054; Fanconi Anaemia; ?Breast cancer, early-onset, 114480; Fanconi Anemia to Fanconi anemia, complementation group J, OMIM:609054
Source NHS GMS was added to BRIP1. Added phenotypes Fanconi anemia, complementation group J, 609054 for gene: BRIP1 Publications for gene BRIP1 were changed from to 21964575
Source Expert List was added to BRIP1. Rating Changed from Green List (high evidence) to Green List (high evidence)
This gene has been classified as Green List (High Evidence).
Model of inheritance for gene BRIP1 was changed to BIALLELIC, autosomal or pseudoautosomal
BRIP1 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: UKGTN
Model of inheritance for gene BRIP1 was changed to BIALLELIC, autosomal or pseudoautosomal
Model of inheritance for gene BRIP1 was changed to BIALLELIC, autosomal or pseudoautosomal
BRIP1 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Illumina TruGenome Clinical Sequencing Services
BRIP1 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Radboud University Medical Center, Nijmegen