Childhood solid tumours
Gene: NF2
As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that there is enough evidence to rate this gene greenCreated: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Acoustic neuroma
Comment on list classification: Bilateral tumours would fulfill eligibility criteria for paediatric tumour syndromes groupCreated: 7 Mar 2016, 11:33 p.m.
Bilateral tumours would fulfill eligibility criteria for paediatric tumour syndromes groupCreated: 7 Mar 2016, 9:50 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
101000
Publications
Comment on list classification: Not syndromic; recognisable pattern of malignancy.Created: 14 Feb 2016, 5:21 p.m.
Source NHS GMS was added to NF2. Mode of inheritance for gene NF2 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Added phenotypes Acoustic neuroma for gene: NF2 Publications for gene NF2 were changed from to 23788249
Source Expert List was added to NF2. Rating Changed from Green List (high evidence) to Green List (high evidence)
Mode of inheritance for NF2 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
This gene has been classified as Green List (High Evidence).
This gene has been classified as Red List (Low Evidence).
This gene has been classified as Red List (Low Evidence).
NF2 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: UKGTN
Model of inheritance for gene NF2 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
NF2 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Illumina TruGenome Clinical Sequencing Services
NF2 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Radboud University Medical Center, Nijmegen