Tumour predisposition - childhood onset

Gene: ATM

Green List (high evidence)

ATM (ATM serine/threonine kinase)
EnsemblGeneIds (GRCh38): ENSG00000149311
EnsemblGeneIds (GRCh37): ENSG00000149311
OMIM: 607585, Gene2Phenotype
ATM is in 29 panels

3 reviews

Ivone Leong (Genomics England Curator)

Green List (high evidence)

As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that there is enough evidence to rate this gene green.
Created: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27

Lara Hawkes (Genomics England)

Green List (high evidence)

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Ataxia Telangiectasia

Richard Scott (Genomics England Curator)

Comment on list classification: Established childhood tumour syndrome
Created: 7 Mar 2016, 11:38 p.m.

History Filter Activity

2 Aug 2019, Gel status: 3

Added New Source, Set Phenotypes, Set publications

Ivone Leong (Genomics England Curator)

Source NHS GMS was added to ATM. Added phenotypes Ataxia Telangiectasia for gene: ATM Publications for gene ATM were changed from 9463314 to 9288106

30 Jan 2019, Gel status: 3

Added New Source, Status Update

Ivone Leong (Genomics England Curator)

Source Expert List was added to ATM. Rating Changed from Green List (high evidence) to Green List (high evidence)

7 Mar 2016, Gel status: 4

Gene classified by Genomics England curator

Richard Scott (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

7 Mar 2016, Gel status: 0

Added New Source

Richard Scott (North Thames GMC/UCL)

ATM was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Expert list

7 Mar 2016, Gel status: 0

Created

Richard Scott (North Thames GMC/UCL)

ATM was created by Reviewer_03