Childhood solid tumours
Gene: NRAS
NRAS (NRAS proto-oncogene, GTPase)
EnsemblGeneIds (GRCh38): ENSG00000213281
EnsemblGeneIds (GRCh37): ENSG00000213281
OMIM: 164790, Gene2Phenotype
NRAS is in 25 panels
EnsemblGeneIds (GRCh38): ENSG00000213281
EnsemblGeneIds (GRCh37): ENSG00000213281
OMIM: 164790, Gene2Phenotype
NRAS is in 25 panels
3 reviews
Ivone Leong (Genomics England Curator)
As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that RASopathy associated genes associated with cancer will be included in this panel and that there is enough evidence to rate this gene green.Created: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Anna de Burca (Oxford University Hospitals NHS Foundation Trust)
Predisposition to cancer.Created: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Publications
Lara Hawkes (Genomics England)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Noonan syndrome
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
- Sources
-
- NHS GMS
- Expert List
- Phenotypes
-
- Cardio-Facio-cutanenous syndrome
- Noonan syndrome 6 613224
- CFC Syndrome
- OMIM
- 164790
- Clinvar variants
- Variants in NRAS
- Penetrance
- None
- Publications
- Panels with this gene
-
- Paediatric or syndromic cardiomyopathy
- Intellectual disability
- Hereditary neuropathy or pain disorder
- Pigmentary skin disorders
- Multiple monogenic benign skin tumours
- Primary lymphoedema
- Cytopenias and congenital anaemias
- COVID-19 research
- Mosaic skin disorders - deep sequencing
- Fetal hydrops
- Fetal anomalies
- Hydrocephalus
- Childhood solid tumours
- Primary immunodeficiency or monogenic inflammatory bowel disease
- Segmental overgrowth disorders - Deep sequencing
- Adult solid tumours cancer susceptibility
- RASopathies
- IUGR and IGF abnormalities
- Monogenic short stature
- Hypertrophic cardiomyopathy
- DDG2P
- Hereditary neuropathy
- Neurological segmental overgrowth
- Early onset or syndromic epilepsy
- Childhood solid tumours cancer susceptibility
History Filter Activity
2 Aug 2019, Gel status: 1
Added New Source, Set mode of inheritance, Set Phenotypes, Set publications
Ivone Leong (Genomics England Curator)Source NHS GMS was added to NRAS. Mode of inheritance for gene NRAS was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Added phenotypes Cardio-Facio-cutanenous syndrome; Noonan syndrome 6 613224; CFC Syndrome for gene: NRAS Publications for gene NRAS were changed from to 23875798
30 Jan 2019, Gel status: 1
Created, Added New Source, Set mode of inheritance
Ivone Leong (Genomics England Curator)gene: NRAS was added gene: NRAS was added to Tumour predisposition - childhood onset. Sources: Expert List Mode of inheritance for gene: NRAS was set to