NRAS

Green NRAS in IUGR and IGF abnormalities

Level 3: Growth hormone disorders
Level 2: Endocrine disorders
Version 1.36

Sources

• Expert Review Green
• Other

Phenotypes

• A restricted spectrum of NRAS mutations causes Noonan syndrome. (Nat Genet. 42: 27-29, 2010.)

Green NRAS in Fetal hydrops

Level 3: Fetal disorders
Level 2: Dysmorphic and congenital abnormality syndromes
Version 1.35

Sources

• Eligibility statement prior genetic testing
• Expert Review Green

Phenotypes

• Noonan syndrome
• Noonan syndrome 6
• Cardio-Facio-cutanenous syndrome
• CFC Syndrome

Amber NRAS in COVID-19 research

Level 2: Viral research
Version 1.79

Sources

• Expert Review Amber
• London North GLH
• GOSH PID v.8.0
• NHS GMS
• GRID V2.0
• North West GLH
• ESID Registry 20171117
• NHS GMS
• North West GLH
• London North GLH
• Expert Review Amber
• ESID Registry 20171117
• GRID V2.0
• GOSH PID v.8.0

Phenotypes

• Ras associated lymphoproliferative disease (RALD)
• Autoimmune lymphoproliferative syndrome type IV
• RAS-associated autoimmune lymphoproliferative syndrome type IV, somatic 614470

Red NRAS in Hydrocephalus

Version 2.116
Latest signed off version: v2.3 (2 Mar 2020)

Sources

• NHS GMS
• Expert Review Red
• Literature

Phenotypes

• Neurocutaneous melanosis, somatic

Red NRAS in Segmental overgrowth disorders

Version 2.14
Latest signed off version: v2.1 (24 Feb 2020)

Sources

• Other

Phenotypes

• Hemimegalencephaly
• Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic, 163200

Red NRAS in Tumour predisposition - childhood onset

Level 3: Childhood Tumours
Level 2: Tumour syndromes
Version 2.23
Latest signed off version: v2.5 (4 Mar 2020)

Sources

• NHS GMS
• Expert List

Phenotypes

• Cardio-Facio-cutanenous syndrome
• Noonan syndrome 6 613224
• CFC Syndrome

Green NRAS in Pigmentary skin disorders

Version 1.15
Latest signed off version: v1.4 (15 Oct 2020)

Sources

• London North GLH
• NHS GMS
• Expert Review Green

Phenotypes

• Congenital melanocytic naevus syndrome
• Melanocytic naevi
• NOONAN SYNDROME 6
• Noonan syndrome
• NS6

Red NRAS in Hypertrophic cardiomyopathy - teen and adult

Level 3: Cardiomyopathy
Level 2: Cardiovascular disorders
Version 2.22
Latest signed off version: v2.11 (15 Oct 2020)

Component of the following Super Panels:

Sources

• South West GLH
• Expert list

Phenotypes

• syndromic HCM

Amber NRAS in Primary immunodeficiency

Version 2.472
Latest signed off version: v2.1 (24 Feb 2020)

Sources

• NHS GMS
• North West GLH
• London North GLH
• Expert Review Amber
• ESID Registry 20171117
• GRID V2.0
• GOSH PID v.8.0

Phenotypes

• ?RAS-associated autoimmune lymphoproliferative syndrome type IV, somatic 614470
• Autoimmune lymphoproliferative syndrome type IV
• Ras associated lymphoproliferative disease (RALD)

Tags

• somatic
• mosaicism

Red NRAS in Cytopenias and congenital anaemias

Level 3: Anaemias and red cell disorders
Level 2: Haematological disorders
Version 1.87

Sources

• Expert Review Red
• BRIDGE consortium (NIHRBR-RD)

Phenotypes

• Myelodysplastic syndrome (MDS), Paediatric

Green NRAS in Mosaic skin disorders - deep sequencing

Version 1.5
Latest signed off version: v1.3 (15 Oct 2020)

Sources

• London North GLH
• NHS GMS
• Expert Review Green

Phenotypes

• Congenital melanocytic naevus syndrome
• Melanocytic naevi
• Noonan syndrome

No list NRAS in Multiple monogenic benign skin tumours

Version 1.12
Latest signed off version: v1.3 (15 Oct 2020)

Sources

• Expert Review Removed
• London North GLH
• NHS GMS

Phenotypes

• Melanocytic naevi
• Noonan syndrome
• Congenital melanocytic naevus syndrome

Tags

• curated_removed

Green NRAS in Childhood solid tumours cancer susceptibility

Level 3: Pertinent cancer susceptibility gene panel
Level 2: Cancer Programme
Version 1.15

Sources

• Expert Review Green
• Expert list

Phenotypes

• Noonan syndrome

Green NRAS in Adult solid tumours cancer susceptibility

Level 3: Pertinent cancer susceptibility gene panel
Level 2: Cancer Programme
Version 2.14
Latest signed off version: v2.2 (18 Feb 2020)

Sources

• NHS GMS
• Expert Review Green

Phenotypes

• Cardio-Facio-cutanenous syndrome
• Noonan syndrome 6 613224
• CFC Syndrome

Green NRAS in Fetal anomalies

Version 1.717
Latest signed off version: v1.92 (21 Aug 2020)

Sources

• PAGE DD-Gene2Phenotype
• Expert Review Green

Phenotypes

• NOONAN SYNDROME TYPE 6

Green NRAS in DDG2P

Version 2.46
Latest signed off version: v2.2 (13 Feb 2020)

Component of the following Super Panels:

Sources

• DD-Gene2Phenotype
• Expert Review Green

Phenotypes

• NOONAN SYNDROME TYPE 6 613224

Red NRAS in Hereditary neuropathy

Level 3: Motor and Sensory Disorders of the PNS
Level 2: Neurology and neurodevelopmental disorders
Version 1.415

Sources

• NHS GMS
• South West GLH
• Emory Genetics Laboratory

Phenotypes

• Cardiomyopathy

Green NRAS in Growth failure in early childhood

Version 1.71
Latest signed off version: v1.4 (3 Mar 2020)

Sources

• Expert Review Green

Phenotypes

• Noonan syndrome
• CFC Syndrome
• A restricted spectrum of NRAS mutations causes Noonan syndrome. (Nat Genet. 42: 27-29, 2010.)
• Noonan syndrome 6
• Cardio-Facio-cutanenous syndrome

Red NRAS in Genetic epilepsy syndromes

Level 3: Inherited Epilepsy Syndromes
Level 2: Neurology and neurodevelopmental disorders
Version 2.429
Latest signed off version: v2.2 (13 Feb 2020)

Sources

• Wessex and West Midlands GLH
• NHS GMS
• Expert Review Red
• Victorian Clinical Genetics Services

Green NRAS in Intellectual disability

Level 3: Neurodevelopmental disorders
Level 2: Neurology and neurodevelopmental disorders
Version 3.1306
Latest signed off version: v3.2 (13 Feb 2020)

Component of the following Super Panels:

Sources

• Expert Review Green
• Radboud University Medical Center, Nijmegen

Phenotypes

• Autoimmune lymphoproliferative syndrome type IV, 614470Noonan syndrome 6, 613224Epidermal nevus, somatic, 162900Thyroid carcinoma, follicular, somatic, 188470Colorectal cancer, somatic, 114500
• NOONAN SYNDROME TYPE 6

Green NRAS in RASopathies

Level 3: RASopathies
Level 2: Dysmorphic and congenital abnormality syndromes
Version 1.75

Sources

• Expert Review Green
• UKGTN
• Eligibility statement prior genetic testing
• Illumina TruGenome Clinical Sequencing Services
• Emory Genetics Laboratory
• Radboud University Medical Center, Nijmegen

Phenotypes

• Noonan syndrome 6 613224
• Cardio-Facio-cutanenous syndrome

Green NRAS in Primary lymphoedema

Level 3: Lymphatic Disorders
Level 2: Cardiovascular disorders
Version 2.18
Latest signed off version: v2.2 (2 Mar 2020)

Sources

• Expert Review Green
• Expert Review

Phenotypes

• Noonan syndrome 6 613224

Red NRAS in Neurological segmental overgrowth

Version 1.15
Latest signed off version: v1.4 (4 Mar 2020)

Component of the following Super Panels:

Sources

• Expert Review Red

Phenotypes

• Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic, 163200
• Hemimegalencephaly

Green NRAS in Cardiomyopathies - including childhood onset

Version 1.54
Latest signed off version: v1.4 (19 Feb 2020)

Sources

• NHS GMS
• Expert List
• South West GLH
• London South GLH
• Expert Review Green

Phenotypes

• CFC Syndrome
• Noonan syndrome
• Noonan syndrome 6
• Noonan syndrome 6 613224
• syndromic HCM
• Cardio-Facio-cutanenous syndrome

Red NRAS in Hereditary neuropathy NOT PMP22 copy number

Version 1.61
Latest signed off version: v1.36 (5 Aug 2021)

Sources

• NHS GMS
• South West GLH
• Emory Genetics Laboratory
• NHS GMS
• South West GLH

Phenotypes

• Cardiomyopathy

Green NRAS in Severe Paediatric Disorders

Version 1.84

Sources

• Next Generation Children Project
• Expert Review Green
• Expert list

Phenotypes

• Noonan syndrome 6, 613224