Hydrocephalus

Gene: NRAS

Red List (low evidence)

NRAS (NRAS proto-oncogene, GTPase)
EnsemblGeneIds (GRCh38): ENSG00000213281
EnsemblGeneIds (GRCh37): ENSG00000213281
OMIM: 164790, Gene2Phenotype
NRAS is in 24 panels

2 reviews

Louise Daugherty (Genomics England Curator)

I don't know

As discussed with the GMS Neurology Specialist Test Group webex call 11th July 2019: The Specialist Test Group all agreed that there is only enough evidence to rate this gene Red
Created: 29 Jul 2019, 2:49 p.m. | Last Modified: 29 Jul 2019, 2:49 p.m.
Panel Version: 1.34

Helen Brittain (Genomics England Curator)

Red List (low evidence)

Somatic mutations are associated with congenital melanosis, presenting as congenital melanocytic naevus syndrome. 18% of a large cohort had neurological involvement, however hydrocephalus was considered a rare association. Therefore not considered appropriate for this panel (rare, presents in a different clear manner, somatic mutations)
Created: 9 May 2017, 1:22 p.m.

Phenotypes
Neurocutaneous melanosis, somatic

Publications

History Filter Activity

29 Jul 2019, Gel status: 1

Added New Source

Louise Daugherty (Genomics England Curator)

Source NHS GMS was added to NRAS.

31 May 2017, Gel status: 1

panel promoted to version 1

Ellen McDonagh (Genomics England Curator)

31.05.2017 - panel revised after internal curation and clinical review.

9 May 2017, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

NRAS was added to Hydrocephaluspanel. Source: Expert Review Red

9 May 2017, Gel status: 0

Created

Helen Brittain (Genomics England Curator)

NRAS was created by helen.brittain

9 May 2017, Gel status: 0

Added New Source

Helen Brittain (Genomics England Curator)

NRAS was added to Hydrocephaluspanel. Sources: Literature