Childhood solid tumours
Gene: WT1
As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that there is enough evidence to rate this gene greenCreated: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Familial Wilms tumor
Some (most) missense mutations in zinc-finger domain are disease causing but rarely inherited, so de novo status is the best handle. PMID 15483024 is a good source.Created: 6 Aug 2015, 3:55 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Publications
Mode of pathogenicity
loss-of-function (truncating variants and curated list of variants)
Source NHS GMS was added to WT1. Mode of inheritance for gene WT1 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Added phenotypes Familial Wilms tumor for gene: WT1 Publications for gene WT1 were changed from 15483024 to 23788249
Source Expert List was added to WT1. Rating Changed from Green List (high evidence) to Green List (high evidence)
This gene has been classified as Green List (High Evidence).
Publications for WT1 were set to 15483024
Mode of inheritance for WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
WT1 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Eligibility statement prior genetic testing,Radboud University Medical Center, Nijmegen,Illumina TruGenome Clinical Sequencing Services,Emory Genetics Laboratory,UKGTN
Phenotypes for gene WT1 were set to Wilms tumor, type 1, 194070; Denys-Drash syndrome, 194080; Nephrotic syndrome, type 4, 256370; Frasier syndrome, 136680; Meacham syndrome, 608978; Mesothelioma, somatic, 156240;Wagner Syndrome;Wilms Tumor;Wilms Tumor 1;Denys-Drash Syndrome; Wilms tumour
Model of inheritance for gene WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Model of inheritance for gene WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Model of inheritance for gene WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Model of inheritance for gene WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
WT1 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: UKGTN
WT1 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Emory Genetics Laboratory
Model of inheritance for gene WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Model of inheritance for gene WT1 was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
WT1 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Illumina TruGenome Clinical Sequencing Services
WT1 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Radboud University Medical Center, Nijmegen