Childhood solid tumours
Gene: PTPN11
As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that RASopathy associated genes associated with cancer will be included in this panel and that there is enough evidence to rate this gene green.Created: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Predisposition to cancer.Created: 2 Aug 2019, 11:03 a.m. | Last Modified: 2 Aug 2019, 11:03 a.m.
Panel Version: 1.27
Publications
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Noonan syndrome
Comment on list classification: Elevated risk of childhood malignancy although absolute risk remains lowCreated: 7 Mar 2016, 11:49 p.m.
Source NHS GMS was added to PTPN11. Mode of inheritance for gene PTPN11 was changed from MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Added phenotypes Noonan syndrome for gene: PTPN11 Publications for gene PTPN11 were changed from 25683281 to 23926459; 23875798
Source Expert List was added to PTPN11. Rating Changed from Green List (high evidence) to Green List (high evidence)
This gene has been classified as Green List (High Evidence).
This gene has been classified as Green List (High Evidence).
PTPN11 was added to Paediatric congenital malformation-dysmorphism-tumour syndromes panel. Sources: Expert list
PTPN11 was created by Reviewer_03