Gastrointestinal epithelial barrier disorders

Gene: IKBKG

Amber List (moderate evidence)

IKBKG (inhibitor of nuclear factor kappa B kinase subunit gamma)
EnsemblGeneIds (GRCh38): ENSG00000269335
EnsemblGeneIds (GRCh37): ENSG00000073009
OMIM: 300248, Gene2Phenotype
IKBKG is in 19 panels

4 reviews

Olivia Niblock (Genomics England Curator)

Comment on list classification: From literature research, it appears that variants in this gene appear to be involved in immunological disorders rather than clearly gastrointestinal disorders. However, given the expert green review, I have promoted this gene to amber.
Created: 26 Jul 2018, 10:30 a.m.
Comment on list classification: From literature research, it appears that variants in this gene appear to be involved in immunological disorders rather than clearly gastrointestinal disorders. However, given the expert green review, I have promoted this gene to amber.
Created: 26 Jul 2018, 10:30 a.m.

Sarah Leigh (Genomics England Curator)

Mode of inheritance
Unknown

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Promoted from amber to green due to expert review and curated evidence.
Created: 12 Oct 2016, 9:07 a.m.

Neil shah (GOSH)

Green List (high evidence)

History Filter Activity

26 Jul 2018, Gel status: 2

Entity classified by Genomics England curator

Olivia Niblock (Genomics England Curator)

Gene: ikbkg has been classified as Amber List (Moderate Evidence).

26 Jul 2018, Gel status: 2

Entity classified by Genomics England curator

Olivia Niblock (Genomics England Curator)

Gene: ikbkg has been classified as Amber List (Moderate Evidence).

25 Jul 2018, Gel status: 1

Panel promoted to version 1.0

Olivia Niblock (Genomics England Curator)

Panel reviews have been assessed and internal clinical team opinion has been sought on this panel, particularly to rule out incidental findings. Panel has been revised through expert review, internal review and literature research. 25/07/2018

17 Apr 2018, Gel status: 1

Added New Source

Olivia Niblock (Genomics England Curator)

Expert list was added to IKBKG. Panel: Gastrointestinal epithelial barrier disorders

17 Apr 2018, Gel status: 1

Added New Source, Set penetrance

Olivia Niblock (Genomics England Curator)

Radboud University Medical Center, Nijmegen was added to IKBKG. Panel: Gastrointestinal epithelial barrier disorders Phenotypes for gene IKBKG were set to Immunodeficiency 33, 300636, Immunodeficiency, isolated, 300584

26 Jan 2017, Gel status: 0

Created

Sarah Leigh (Genomics England Curator)

IKBKG was created by sleigh

26 Jan 2017, Gel status: 0

Added New Source

Sarah Leigh (Genomics England Curator)

IKBKG was added to Gastrointestinal epithelial barrier disorderspanel. Sources: Eligibility statement prior genetic testing