ICOS

inducible T-cell costimulator
OMIM: 604558, Gene2Phenotype

5 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 5 panels
Green ICOS in Infantile enterocolitis & monogenic inflammatory bowel disease Level 3: Gastrointestinal disorders Level 2: Gastroenterological disorders Version 1.45	review	BIALLELIC, autosomal or pseudoautosomal	Sources Emory Genetics Laboratory UKGTN Radboud University Medical Center, Nijmegen Illumina TruGenome Clinical Sequencing Services Expert list Phenotypes Immunodeficiency, common variable, 1 607594
Green ICOS in Gastrointestinal epithelial barrier disorders Level 3: Gastrointestinal disorders Level 2: Gastroenterological disorders Version 1.76	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Emory Genetics Laboratory Phenotypes Early Onset Inflammatory Bowel Disease Immunodeficiency, common variable, 1 607594
Green ICOS in COVID-19 research Level 2: Viral research Version 1.146	review	BIALLELIC, autosomal or pseudoautosomal	Sources IUIS Classification February 2018 A- or hypo-gammaglobulinaemia v1.25 London North GLH GOSH PID v.8.0 NHS GMS GRID V2.0 Victorian Clinical Genetics Services North West GLH ESID Registry 20171117 Expert Review Green NHS GMS North West GLH London North GLH Expert Review Green IUIS Classification February 2018 Victorian Clinical Genetics Services ESID Registry 20171117 GRID V2.0 GOSH PID v.8.0 A- or hypo-gammaglobulinaemia v1.25 Phenotypes combined immunodeficiency Isolated IgG subclass deficiency gammaglobulinaemia Immunodeficiency, common variable, 1, 607594 Immunodeficiencies affecting cellular and humoral immunity Common variable immunodeficiency disorders (CVID) hypogammaglobulinaemia Immunodeficiency, common variable, 1 Recurrent infections, autoimmunity, gastroenteritis, granulomas
Green ICOS in Intestinal failure or congenital diarrhoea Level 2: Gastrohepatology Version 3.7 Latest signed off version: v3.0 (22 Mar 2023)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Phenotypes Immunodeficiency, common variable, 1, OMIM:607594
Green ICOS in Primary immunodeficiency or monogenic inflammatory bowel disease Level 2: Immunology Version 8.78 Latest signed off version: v8.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Other NHS GMS North West GLH London North GLH IUIS Classification February 2018 Victorian Clinical Genetics Services ESID Registry 20171117 GRID V2.0 GOSH PID v.8.0 A- or hypo-gammaglobulinaemia v1.25 Phenotypes Immunodeficiency, common variable, 1 Immunodeficiency, common variable, 1, 607594 Common variable immunodeficiency disorders (CVID) Isolated IgG subclass deficiency hypogammaglobulinaemia gammaglobulinaemia combined immunodeficiency Recurrent infections, autoimmunity, gastroenteritis, granulomas Immunodeficiencies affecting cellular and humoral immunity Tags deletions