INS

insulin
OMIM: 176730, Gene2Phenotype

6 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 6 panels
Red INS in Genomic imprinting Version 0.149	review	MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)	Sources Literature
No list INS in Multi-organ autoimmune diabetes Level 3: Disorders of unusual phenotypes Level 2: Endocrine disorders Version 1.11	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Removed UKGTN Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Phenotypes Hyperproinsulinemia, familial, with or without diabetes Maturity-onset diabetes of the young, type 10, 613370 Diabetes mellitus, permanent neonatal, 606176 Diabetes mellitus, type 1, 125852 Diabetes mellitus, insulin-dependent, 2, 125852 Maturity Onset Diabetes of the Young Transient Neonatal Diabetes, Dominant/Recessive Neonatal Diabetes Monogenic Diabetes Tags curated_removed
Green INS in Diabetes with additional phenotypes suggestive of a monogenic aetiology Level 3: Disorders of unusual phenotypes Level 2: Endocrine disorders Version 1.67	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources Expert Review Green UKGTN Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Phenotypes Hyperproinsulinemia, familial, with or without diabetes Maturity-onset diabetes of the young, type 10, 613370 Diabetes mellitus, permanent neonatal, 606176 Diabetes mellitus, type 1, 125852 Diabetes mellitus, insulin-dependent, 2, 125852 Maturity Onset Diabetes of the Young Transient Neonatal Diabetes, Dominant/Recessive Permanent Neonatal diabetes mellitus MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 10 MODY10
Green INS in Neonatal diabetes Level 3: Disorders of unusual phenotypes Level 2: Endocrine disorders Version 4.4 Latest signed off version: v4.0 (22 Mar 2023)	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources NHS GMS Expert Review Green Eligibility statement prior genetic testing UKGTN Illumina TruGenome Clinical Sequencing Services Radboud University Medical Center, Nijmegen Phenotypes Hyperproinsulinemia, OMIM:616214 Maturity-onset diabetes of the young, type 10, 613370 Diabetes mellitus, insulin-dependent, 2, 125852 Transient Neonatal Diabetes Mellitus (disease), MONDO:0020525 (Dominant/Recessive) Permanent Neonatal diabetes mellitus, MONDO:010016
Green INS in Familial diabetes Level 3: Disorders of unusual phenotypes Level 2: Endocrine disorders Version 1.67	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources NHS GMS Expert Review Green UKGTN Radboud University Medical Center, Nijmegen Illumina TruGenome Clinical Sequencing Services Phenotypes Maturity Onset Diabetes of the Young Hyperproinsulinemia, familial, with or without diabetes Transient Neonatal Diabetes, Dominant/Recessive Maturity Onset Diabetes of the Young (Dominant)
Green INS in Monogenic diabetes Version 2.58 Latest signed off version: v2.2 (25 Feb 2020)	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources NHS GMS Expert Review Green Phenotypes Maturity-onset diabetes of the young, type 10, OMIM:613370 Diabetes mellitus, permanent neonatal 4, OMIM:618858 Diabetes mellitus, insulin-dependent, 2, OMIM:125852 Hyperproinsulinemia, OMIM:616214