Familial diabetes
Gene: INS
Initial gene list and info collated by Sian Ellard, University of Exeter Medical School, August 2018 on behalf of the GMS Endocrinology specialist test group. Gene Symbol submitted: INS; Suggested intial gene rating: Green; Evidence for inclusion: none given; Evidence for exclusion: none given; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none given; Phenotypes: Diabetes.Created: 11 Jan 2019, 10:04 a.m.
Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
The Illumina comment is incorrect; most dominant mutations cause permanent neonatal diabetes rather than MODY.Created: 23 Aug 2015, 3:55 p.m.
Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Variants in this GENE are reported as part of current diagnostic practice
From Illumina information for this gene, the phenotype "Transient Neonatal Diabetes, Dominant/Recessive" was recorded with a recessive mode of inheritance, and "Maturity Onset Diabetes of the Young" with a dominant mode of inheritance.Created: 2 Jul 2015, 8:39 a.m.
This gene has been classified as Green List (High Evidence).
INS was added to Familial diabetespanel. Sources: UKGTN
INS was added to Familial diabetespanel. Sources: Radboud University Medical Center, Nijmegen
INS was added to Familial diabetespanel. Sources: Illumina TruGenome Clinical Sequencing Services