Familial diabetes

Gene: LIPC

Red List (low evidence)

LIPC (lipase C, hepatic type)
EnsemblGeneIds (GRCh38): ENSG00000166035
EnsemblGeneIds (GRCh37): ENSG00000166035
OMIM: 151670, Gene2Phenotype
LIPC is in 7 panels

3 reviews

Ivone Leong (Genomics England Curator)

Red List (low evidence)

Gene changed to grey status after consultation with Professor Sian Ellard (South West GLH) that this gene is not appropriate for the panel.
Created: 25 Jan 2019, 11:49 a.m.

Ellen McDonagh (Genomics England Curator)

Red List (low evidence)

Sian Ellard (University of Exeter Medical School)

No evidence to support this being a monogenic diabetes gene - included in error?
Created: 23 Aug 2015, 4:50 p.m.

Details

Sources
  • Expert Review Removed
  • Expert Review Red
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • [High density lipoprotein cholesterol level QTL 12], 612797
  • {Diabetes mellitus, noninsulin-dependent}, 125853
  • Hepatic lipase deficiency, 614025
OMIM
151670
Clinvar variants
Variants in LIPC
Penetrance
Complete
Panels with this gene

History Filter Activity

15 Jun 2016, Gel status: 1

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

27 Aug 2015, Gel status: 1

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for gene LIPC were set to [High density lipoprotein cholesterol level QTL 12], 612797; {Diabetes mellitus, noninsulin-dependent}, 125853; Hepatic lipase deficiency, 614025

28 Apr 2015, Gel status: 1

Added New Source

GEL ()

LIPC was added to Familial diabetespanel. Sources: Radboud University Medical Center, Nijmegen