Familial diabetes

Gene: DYRK1B

Green List (high evidence)

DYRK1B (dual specificity tyrosine phosphorylation regulated kinase 1B)
EnsemblGeneIds (GRCh38): ENSG00000105204
EnsemblGeneIds (GRCh37): ENSG00000105204
OMIM: 604556, Gene2Phenotype
DYRK1B is in 2 panels

1 review

Ivone Leong (Genomics England Curator)

Green List (high evidence)

Comment on list classification: Promoted from red to green as advised via email communication with Jane Houghton (South West GLH).
Created: 28 Jan 2019, 9:39 a.m.
Initial gene list and info collated by Sian Ellard, University of Exeter Medical School, August 2018 on behalf of the GMS Endocrinology specialist test group. Gene Symbol submitted: DYRK1B; Suggested intial gene rating: Green; Evidence for inclusion: none given; Evidence for exclusion: none given; Technical notes (e.g. non-coding/CNV mutations requiring coverage?): none given; Phenotypes: Metabolic syndrome (coronary artery disease, hypertension, central obesity and diabetes).
Created: 11 Jan 2019, 10:04 a.m.

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • NHS GMS
  • Expert Review Green
  • Expert Review Green
  • NHS GMS
Phenotypes
  • Abdominal obesity-metabolic syndrome 3, 615812
OMIM
604556
Clinvar variants
Variants in DYRK1B
Penetrance
None
Panels with this gene

History Filter Activity

1 Mar 2019, Gel status: 4

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: DYRK1B were changed from to Abdominal obesity-metabolic syndrome 3, 615812

1 Mar 2019, Gel status: 4

Created, Added New Source, Set mode of inheritance

Ivone Leong (Genomics England Curator)

gene: DYRK1B was added gene: DYRK1B was added to Familial diabetes. Sources: Expert Review Green,NHS GMS Mode of inheritance for gene: DYRK1B was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown