Diabetes with additional phenotypes suggestive of a monogenic aetiology
Gene: INS
Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
From Illumina information for this gene, the phenotype "Transient Neonatal Diabetes, Dominant/Recessive" was recorded with a recessive mode of inheritance, and "Maturity Onset Diabetes of the Young" with a dominant mode of inheritance.Created: 2 Jul 2015, 8:39 a.m.
25th July 2016: Panel revised acccording to expert review, further evidence sources and comparison with the Familial Diabetes version 1 panel. Promoted to version 1.
This gene has been classified as Green List (High Evidence).
Model of inheritance for gene INS was changed to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Model of inheritance for gene INS was changed to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Model of inheritance for gene INS was changed to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Model of inheritance for gene INS was changed to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Model of inheritance for gene INS was changed to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Model of inheritance for gene INS was changed to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Model of inheritance for gene INS was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Model of inheritance for gene INS was changed to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
INS was added to Diabetes with additional phenotypes suggestive of a monogenic aetiologypanel. Sources: UKGTN
Model of inheritance for gene INS was changed to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Model of inheritance for gene INS was changed to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
INS was added to Diabetes with additional phenotypes suggestive of a monogenic aetiologypanel. Sources: Illumina TruGenome Clinical Sequencing Services
INS was added to Diabetes with additional phenotypes suggestive of a monogenic aetiologypanel. Sources: Radboud University Medical Center, Nijmegen