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  2. Diabetes with additional phenotypes suggestive of a monogenic aetiology
  3. MT-TL1
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Diabetes with additional phenotypes suggestive of a monogenic aetiology

Gene: MT-TL1

Green List (high evidence)
MT-TL1 (mitochondrially encoded tRNA leucine 1 (UUA/G))
EnsemblGeneIds (GRCh38): ENSG00000209082
EnsemblGeneIds (GRCh37): ENSG00000209082
OMIM: 590050, Gene2Phenotype
MT-TL1 is in 23 panels

2 reviews

Sian Ellard (University of Exeter Medical School)

Green List (high evidence)

Created: 5 Nov 2017, 2:39 a.m.

Panel version: 0

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Promoted from red to green due to expert review.
Created: 22 Jul 2016, 12:13 p.m.
Created: 22 Jul 2016, 12:13 p.m.

Panel version: 0.64

History Filter Activity

15 Jul 2024, Gel status: 3

Added Tag

Sarah Leigh (Genomics England Curator)

Tag locus-type-rna-transfer tag was added to gene: MT-TL1.

4 May 2022, Gel status: 3

Added Tag

Arina Puzriakova (Genomics England Curator)

Tag gene-checked tag was added to gene: MT-TL1.

25 Jul 2016, Gel status: 4

panel promoted to version 1

Ellen McDonagh (Genomics England Curator)

25th July 2016: Panel revised acccording to expert review, further evidence sources and comparison with the Familial Diabetes version 1 panel. Promoted to version 1.

22 Jul 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

22 Jul 2016, Gel status: 4

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for MT-TL1 were set to MELAS syndrome; Diabetes-Deafness Syndrome, Maternally Transmitted; DIABETES AND DEAFNESS, MATERNALLY INHERITED; MIDD

22 Jul 2016, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

17 Aug 2015, Gel status: 1

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene MT-TL1 was changed to MITOCHONDRIAL

17 Aug 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

MT-TL1 was added to Diabetes with additional phenotypes suggestive of a monogenic aetiologypanel. Sources: Eligibility statement prior genetic testing

17 Aug 2015, Gel status: 1

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene MT-TL1 was changed to MITOCHONDRIAL

20 Jul 2015, Gel status: 1

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene MT-TL1 was changed to MITOCHONDRIAL

17 Jul 2015, Gel status: 1

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Model of inheritance for gene MT-TL1 was changed to MITOCHONDRIAL

17 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

MT-TL1 was added to Diabetes with additional phenotypes suggestive of a monogenic aetiologypanel. Sources: UKGTN