Diabetes with additional phenotypes suggestive of a monogenic aetiology

Gene: IL1RN

No list

IL1RN (interleukin 1 receptor antagonist)
EnsemblGeneIds (GRCh38): ENSG00000136689
EnsemblGeneIds (GRCh37): ENSG00000136689
OMIM: 147679, Gene2Phenotype
IL1RN is in 5 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

Remove gene from the panel.
Created: 19 Oct 2015, 8:16 a.m.

Sian Ellard (University of Exeter Medical School)

no evidence that mutations cause monogenic diabetes
Created: 18 Oct 2015, 8:20 a.m.

Details

Sources
  • Expert Review Removed
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • {Gastric cancer risk after H. pylori infection}, 137215
  • {Microvascular complications of diabetes 4}, 612628
  • Interleukin 1 receptor antagonist deficiency, 612852
OMIM
147679
Clinvar variants
Variants in IL1RN
Penetrance
Complete
Panels with this gene

History Filter Activity

25 Jul 2016, Gel status: 0

panel promoted to version 1

Ellen McDonagh (Genomics England Curator)

25th July 2016: Panel revised acccording to expert review, further evidence sources and comparison with the Familial Diabetes version 1 panel. Promoted to version 1.

22 Jul 2016, Gel status: 0

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been removed from the panel.

7 Jun 2016, Gel status: 0

Gene classified by Genomics England curator

Chris Boustred (Genomics England)

This gene has been removed from the panel.

17 Jul 2015, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

IL1RN was added to Diabetes with additional phenotypes suggestive of a monogenic aetiologypanel. Sources: Radboud University Medical Center, Nijmegen