LYRM7

LYR motif containing 7
OMIM: 615831, Gene2Phenotype

9 panels

Panel Reviews Mode of inheritance Details
9 panels

Green LYRM7 in White matter disorders and cerebral calcification - narrow panel


Version 1.14
Signed off v.1.12 on 2 Mar 2020

Component of the following Super Panels:

  • White matter disorders - childhood onset
  • review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    Phenotypes
    • Mitochondrial complex III deficiency, nuclear type 8
    • leukoencephalopathy and complex III deficiency
    • 615838
    • severe encephalopathy, lactic acidosis and profound, isolated cIII deficiency in skeletal muscle

    Green LYRM7 in Inherited white matter disorders

    Level 3: White matter disorders
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.71

    review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Literature
    Phenotypes
    • Mitochondrial complex III deficiency, nuclear type 8
    • 615838
    • leukoencephalopathy and complex III deficiency
    • severe encephalopathy, lactic acidosis and profound, isolated cIII deficiency in skeletal muscle

    Green LYRM7 in Mitochondrial disorder with complex III deficiency


    Version 1.3
    Signed off v.1.2 on 17 Feb 2020

    review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • Expert Review Green
    Phenotypes
    • Mitochondrial complex III deficiency, nuclear type 8, 615838

    Green LYRM7 in Inborn errors of metabolism


    Version 2.8
    Signed off v.2.3 on 17 Feb 2020

    Component of the following Super Panels:

  • Hypotonic infant
  • Paediatric disorders
  • White matter disorders - childhood onset
  • review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Expert Review Green
    Phenotypes
    • Mitochondrial complex III deficiency, nuclear type 8
    • Isolated complex III deficiency
    • severe encephalopathy, lactic acidosis and profound, isolated cIII deficiency in skeletal muscle
    • leukoencephalopathy and complex III deficiency
    • 615838

    Green LYRM7 in Possible mitochondrial disorder - nuclear genes


    Version 1.15
    Signed off v.1.13 on 17 Feb 2020

    review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • NHS GMS
    • Expert Review Green
    Phenotypes
    • Mitochondrial complex III deficiency, nuclear type 8, 615838

    No list LYRM7 in Intellectual disability

    Level 3: Neurodevelopmental disorders
    Level 2: Neurology and neurodevelopmental disorders
    Version 3.66
    Signed off v.3.2 on 13 Feb 2020

    Component of the following Super Panels:

  • Hypotonic infant
  • Paediatric disorders
  • White matter disorders - childhood onset
  • review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert list
    Phenotypes
    • Mitochondrial complex III deficiency, nuclear type 8, MIM#615838

    Green LYRM7 in Mitochondrial disorders

    Level 3: Mitochondrial
    Level 2: Metabolic disorders
    Version 2.6
    Signed off v.2.4 on 17 Feb 2020

    Component of the following Super Panels:

  • White matter disorders - childhood onset
  • review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Green
    • Victorian Clinical Genetics Services
    • Expert list
    • Expert
    Phenotypes
    • Isolated complex III deficiency
    • Mitochondrial complex III deficiency, nuclear type 8
    • 615838
    • leukoencephalopathy and complex III deficiency
    • severe encephalopathy, lactic acidosis and profound, isolated cIII deficiency in skeletal muscle

    Red LYRM7 in Cardiomyopathies - including childhood onset


    Version 1.5
    Signed off v.1.4 on 19 Feb 2020

    review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Expert Review Red
    • MetBioNet
    • NHS GMS
    Phenotypes
    • Mitochondrial complex III deficiency, nuclear type 8, 615838

    Green LYRM7 in Severe Paediatric Disorders


    Version 1.6

    review BIALLELIC, autosomal or pseudoautosomal
    Sources
    • Next Generation Children Project
    • Expert Review Green
    • Expert list
    Phenotypes
    • Mitochondrial complex III deficiency, nuclear type 8, 615838