MORC2

MORC family CW-type zinc finger 2
OMIM: 616661, Gene2Phenotype

9 panels

Panel Reviews Mode of inheritance Details
9 panels

Green MORC2 in Ataxia and cerebellar anomalies - narrow panel


Version 2.39
Signed off v.2.23 on 8 Oct 2020

Component of the following Super Panels:

  • Hereditary ataxia and cerebellar anomalies - childhood onset
  • review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Green
    • Expert list
    Phenotypes
    • Axonal type CMT disease type 2Z, 616688

    Amber MORC2 in Severe microcephaly

    Level 3: DNA repair disorders
    Level 2: Dysmorphic and congenital abnormality syndromes
    Version 2.89
    Signed off v.2.2 on 2 Mar 2020

    review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Amber
    • Literature
    Phenotypes
    • Developmental delay
    • Intellectual disability
    • Growth retardation
    • Microcephaly
    • Craniofacial dysmorphism
    • Charcot-Marie-Tooth disease, axonal, type 2Z, OMIM:616688
    Tags
    • for-review

    Red MORC2 in DDG2P


    Version 2.18
    Signed off v.2.2 on 13 Feb 2020

    Component of the following Super Panels:

  • Paediatric disorders
  • review Not set
    Sources
    • DD-Gene2Phenotype
    • Expert Review Red
    Phenotypes
    • MORC2 - axonal neuropathy

    Green MORC2 in Hereditary neuropathy

    Level 3: Motor and Sensory Disorders of the PNS
    Level 2: Neurology and neurodevelopmental disorders
    Version 1.383

    review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • South West GLH
    • NHS GMS
    • London North GLH
    • Expert Review Green
    • Literature
    Phenotypes
    • Charcot-Marie-Tooth disease, axonal, type 2Z 616688
    • Charcot-Marie-Tooth disease, axonal, type 2Z, 616688
    • axonal Charcot-Marie-Tooth disease

    Amber MORC2 in Hearing loss

    Level 3: Non-syndromic hearing loss
    Level 2: Hearing and ear disorders
    Version 2.146
    Signed off v.2.5 on 13 Feb 2020

    review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Amber
    • Literature
    Phenotypes
    • Sensorineural hearing loss
    • Developmental delay
    • Intellectual disability
    • Growth retardation
    • Microcephaly
    • Craniofacial dysmorphism
    • Charcot-Marie-Tooth disease, axonal, type 2Z, OMIM:616688
    Tags
    • for-review

    Amber MORC2 in Intellectual disability

    Level 3: Neurodevelopmental disorders
    Level 2: Neurology and neurodevelopmental disorders
    Version 3.740
    Signed off v.3.2 on 13 Feb 2020

    Component of the following Super Panels:

  • Hypotonic infant
  • Paediatric disorders
  • White matter disorders - childhood onset
  • review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Expert Review Amber
    • Literature
    Phenotypes
    • Developmental delay
    • Intellectual disability
    • Growth retardation
    • Microcephaly
    • Craniofacial dysmorphism
    • Charcot-Marie-Tooth disease, axonal, type 2Z, OMIM:616688
    Tags
    • for-review

    Amber MORC2 in Hereditary ataxia - adult onset


    Version 2.20
    Signed off v.2.13 on 6 Oct 2020

    review MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
    Sources
    • Expert Review Amber
    • London North GLH
    • NHS GMS
    • Wessex and West Midlands GLH
    Phenotypes
    • Axonal type CMT disease type 2Z, 616688

    Green MORC2 in Hereditary neuropathy NOT PMP22 copy number


    Version 1.21
    Signed off v.1.2 on 27 Feb 2020

    review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • South West GLH
    • Literature
    • Expert Review Green
    • London North GLH
    • NHS GMS
    • South West GLH
    • NHS GMS
    • London North GLH
    Phenotypes
    • Charcot-Marie-Tooth disease, axonal, type 2Z

    Green MORC2 in Severe Paediatric Disorders


    Version 1.43

    review MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
    Sources
    • Next Generation Children Project
    • Expert Review Green
    • Expert list
    Phenotypes
    • Charcot-Marie-Tooth disease, axonal, type 2Z, 616688