RNASEH2C

ribonuclease H2 subunit C
OMIM: 610330, Gene2Phenotype

17 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 17 panels
Red RNASEH2C in Juvenile dermatomyositis Level 3: Multi-system inflammatory/autoimmune disorders Level 2: Rheumatological disorders Version 1.4	review	Not set	Sources Expert list Phenotypes Aicardi Goutieres Syndrome
Green RNASEH2C in COVID-19 research Level 2: Viral research Version 1.146	review	BIALLELIC, autosomal or pseudoautosomal	Sources IUIS Classification February 2018 London North GLH NHS GMS GRID V2.0 Victorian Clinical Genetics Services North West GLH ESID Registry 20171117 Expert Review Green NHS GMS North West GLH London North GLH IUIS Classification February 2018 Victorian Clinical Genetics Services Expert Review Green ESID Registry 20171117 GRID V2.0 Phenotypes Aicardi-Goutieres syndrome 3 610329 Autoinflammatory Disorders Type 1 interferonopathies Classical AGS
Red RNASEH2C in Early onset dystonia Level 3: Motor Disorders of the CNS Level 2: Neurology and neurodevelopmental disorders Version 1.152	review	Not set	Sources Emory Genetics Laboratory Phenotypes Dystonia
Green RNASEH2C in White matter disorders and cerebral calcification - narrow panel Level 2: Neurology Version 7.15 Latest signed off version: v7.0 (30 Apr 2025) Component of the following Super Panels: Childhood onset leukodystrophy	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Phenotypes Aicardi-Goutieres Syndrome 3 Aicardi-Goutieres Syndrome General Leukodystrophy & Mitochondrial Leukoencephalopathy Aicardi-Goutieres syndrome 3
Green RNASEH2C in Adult onset leukodystrophy Level 2: Neurology Version 6.10 Latest signed off version: v6.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green NHS GMS Yorkshire and North East GLH Phenotypes Aicardi-Goutieres syndrome 3, 610329
Green RNASEH2C in Primary immunodeficiency or monogenic inflammatory bowel disease Level 2: Immunology Version 8.84 Latest signed off version: v8.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources NHS GMS North West GLH London North GLH IUIS Classification February 2018 Victorian Clinical Genetics Services Expert Review Green ESID Registry 20171117 GRID V2.0 Phenotypes Aicardi-Goutieres syndrome 3 610329 Type 1 interferonopathies Classical AGS Autoinflammatory Disorders
Green RNASEH2C in Intracerebral calcification disorders Level 3: Parenchymal brain disorders Level 2: Neurology and neurodevelopmental disorders Version 1.36	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Emory Genetics Laboratory Illumina TruGenome Clinical Sequencing Services Other Eligibility statement prior genetic testing UKGTN Phenotypes Aicardi-Goutieres syndrome 3 Aicardi-Goutieres Syndrome
Green RNASEH2C in Inherited white matter disorders Level 3: White matter disorders Level 2: Neurology and neurodevelopmental disorders Version 1.186	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Expert list Phenotypes Aicardi-Goutieres Syndrome 3 General Leukodystrophy & Mitochondrial Leukoencephalopathy
Red RNASEH2C in Adult onset neurodegenerative disorder Level 2: Neurology Version 8.16 Latest signed off version: v8.0 (30 Apr 2025)	review	Unknown	Sources Expert Review Red Phenotypes Dystonia
Red RNASEH2C in Undiagnosed metabolic disorders Level 3: Specific metabolic abnormalities Level 2: Metabolic disorders Version 1.643	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Red Literature Phenotypes (Disorders of nucleotide metabolism, Aicardi-Gouti res Syndrome) AGS3 Inherited white matter disorders Intellectual disability Intracerebral calcification disorders
Green RNASEH2C in Likely inborn error of metabolism Level 2: Metabolic Version 8.98 Latest signed off version: v8.0 (30 Apr 2025) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders Unexplained death in infancy and sudden unexplained death in childhood	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green London North GLH NHS GMS Phenotypes Intellectual disability (Disorders of nucleotide metabolism, Aicardi-Gouti res Syndrome) AGS3 Intracerebral calcification disorders Inherited white matter disorders
Green RNASEH2C in Fetal anomalies Level 2: Fetal (including NIPD) Version 6.157 Latest signed off version: v6.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources PAGE DD-Gene2Phenotype Expert Review Green Phenotypes AICARDI-GOUTIERES SYNDROME 3
Green RNASEH2C in DDG2P Version 6.426 Latest signed off version: v6.0 (30 Apr 2025) Component of the following Super Panels: Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources DD-Gene2Phenotype Expert Review Green Phenotypes AICARDI-GOUTIERES SYNDROME 3 610329
Green RNASEH2C in Early onset or syndromic epilepsy Level 2: Neurology Version 8.147 Latest signed off version: v8.0 (30 Apr 2025) Component of the following Super Panels: Paediatric disorders Unexplained death in infancy and sudden unexplained death in childhood	review	BIALLELIC, autosomal or pseudoautosomal	Sources Wessex and West Midlands GLH NHS GMS Expert Review Green Victorian Clinical Genetics Services Phenotypes Aicardi-Goutieres syndrome 3, 610329
Green RNASEH2C in Intellectual disability Level 2: Developmental disorders Version 9.304 Latest signed off version: v9.0 (30 Apr 2025) Component of the following Super Panels: Childhood onset leukodystrophy Hypotonic infant Paediatric disorders	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Radboud University Medical Center, Nijmegen Phenotypes Aicardi-Goutieres syndrome 3, 610329 AICARDI-GOUTIERES SYNDROME 3
Red RNASEH2C in Adult onset dystonia, chorea or related movement disorder Level 2: Neurology Version 5.5 Latest signed off version: v5.0 (30 Apr 2025)	review	Not set	Sources NHS GMS South West GLH Expert Review Red Phenotypes Aicardi-Goutieres syndrome 3, 610329 Dystonia
Green RNASEH2C in Childhood onset dystonia, chorea or related movement disorder Level 2: Neurology Version 7.17 Latest signed off version: v7.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources South West GLH Expert Review Green London North GLH Phenotypes Aicardi-Goutieres syndrome 3, 610329 Tags founder-effect