TNFRSF11A

TNF receptor superfamily member 11a
OMIM: 603499, Gene2Phenotype

10 panels

Panel	Reviews	Mode of inheritance	Details
Filter panels 10 panels
Green TNFRSF11A in COVID-19 research Level 2: Viral research Version 1.146	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green IUIS Classification February 2018 IUIS Classification December 2019 London North GLH NHS GMS North West GLH IUIS Classification December 2019 North West GLH London North GLH NHS GMS IUIS Classification February 2018 Phenotypes Osteopetrosis Defects in intrinsic and innate immunity Defects in Intrinsic and Innate Immunity
Green TNFRSF11A in Hydrocephalus Level 2: Neurology Version 5.8 Latest signed off version: v5.0 (7 Aug 2024)	review	BIALLELIC, autosomal or pseudoautosomal	Sources Expert Review Green Expert list Phenotypes Osteopetrosis, autosomal recessive 7, OMIM:612301
Red TNFRSF11A in Childhood solid tumours Level 2: Cancer susceptibility Version 5.9 Latest signed off version: v5.0 (30 Apr 2025)	review	Not set	Sources Expert List
Amber TNFRSF11A in Primary immunodeficiency or monogenic inflammatory bowel disease Level 2: Immunology Version 8.78 Latest signed off version: v8.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources IUIS Classification December 2019 Expert Review Amber North West GLH London North GLH NHS GMS IUIS Classification February 2018 Phenotypes Osteopetrosis Defects in Intrinsic and Innate Immunity Defects in intrinsic and innate immunity
Red TNFRSF11A in Sarcoma cancer susceptibility Level 3: Pertinent cancer susceptibility gene panel Level 2: Cancer Programme Version 1.26	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources Expert Review Red Expert list Phenotypes Paget disease of bone Polyostotic osteolytic dysplasia (hereditary expansile) Osteosarcoma
Green TNFRSF11A in Skeletal dysplasia Level 2: Musculoskeletal Version 8.34 Latest signed off version: v8.0 (30 Apr 2025) Component of the following Super Panels: Paediatric disorders	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources NHS GMS Expert Review Green Emory Genetics Laboratory Phenotypes Osteolysis, familial expansile 174810 Osteopetrosis, autosomal recessive 7 612301 Paget disease of bone 2, early-onset 602080
Amber TNFRSF11A in Fetal anomalies Level 2: Fetal (including NIPD) Version 6.140 Latest signed off version: v6.0 (30 Apr 2025)	review	BIALLELIC, autosomal or pseudoautosomal	Sources NHS GMS Expert Review Amber Phenotypes Osteopetrosis, autosomal recessive 7, OMIM:612301
Red TNFRSF11A in Osteogenesis imperfecta Level 2: Musculoskeletal Version 5.4 Latest signed off version: v5.0 (30 Apr 2025)	review	Not set	Sources Expert Review Red Emory Genetics Laboratory Phenotypes Osteogenesis Imperfecta and Decreased Bone Density skeletal dysplasias
Red TNFRSF11A in Sarcoma susceptibility Level 2: Cancer susceptibility Version 1.82 Latest signed off version: v1.2 (18 Feb 2020)	review	MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown	Sources NHS GMS Expert Review Red Expert Review Red Expert list Phenotypes {Paget disease of bone 2, early-onset}, OMIM:602080 Osteosarcoma (disease), MONDO:0009807
Green TNFRSF11A in Osteopetrosis Level 2: Musculoskeletal Version 1.38 Latest signed off version: v1.1 (21 Sep 2020)	review	BOTH monoallelic and biallelic, autosomal or pseudoautosomal	Sources NHS GMS Expert Review Green Phenotypes {Paget disease of bone 2, early-onset} OMIM:602080 Osteopetrosis, autosomal recessive 7 OMIM:612301