Sarcoma susceptibility

Gene: TNFRSF11A

Red List (low evidence)

TNFRSF11A (TNF receptor superfamily member 11a)
EnsemblGeneIds (GRCh38): ENSG00000141655
EnsemblGeneIds (GRCh37): ENSG00000141655
OMIM: 603499, Gene2Phenotype
TNFRSF11A is in 7 panels

1 review

Ellen McDonagh (Genomics England Curator)

Gene and evidence provided by Adrienne Flanagan, UCL. Comment from Adrienne on the evidence for this gene: "TNFRSF11A is linked to familial Pagetic bone disease and Pagetic bone disease is associated with sarcoma…although the body of evidence linking TNFRSF11A and osteosarcoma is limited."
Created: 14 May 2018, 3:49 p.m.

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • NHS GMS
  • Expert Review Red
  • Expert Review Red
  • Expert list
Phenotypes
  • Paget disease of bone
  • Polyostotic osteolytic dysplasia (hereditary expansile)
  • Osteosarcoma
OMIM
603499
Clinvar variants
Variants in TNFRSF11A
Penetrance
None
Publications
Panels with this gene

History Filter Activity

1 Aug 2019, Gel status: 1

Added New Source

Rebecca Foulger (Genomics England curator)

Source NHS GMS was added to TNFRSF11A.

23 Jul 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: TNFRSF11A was added gene: TNFRSF11A was added to Sarcoma susceptibility. Sources: Expert Review Red Mode of inheritance for gene: TNFRSF11A was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: TNFRSF11A were set to 15758393; 12673693; 11351498 Phenotypes for gene: TNFRSF11A were set to Paget disease of bone; Polyostotic osteolytic dysplasia (hereditary expansile); Osteosarcoma