Sarcoma susceptibility
Gene: KRASEnsemblGeneIds (GRCh38): ENSG00000133703
EnsemblGeneIds (GRCh37): ENSG00000133703
OMIM: 190070, Gene2Phenotype
KRAS is in 30 panels
3 reviews
Arina Puzriakova (Genomics England Curator)
Comment on mode of inheritance: One case with somatic mosaicism (PMID: 20805368)Created: 12 Mar 2021, 11:44 a.m. | Last Modified: 12 Mar 2021, 11:44 a.m.
Panel Version: 1.63
Ellen McDonagh (Genomics England Curator)
This gene was added to this panel after feedback from Laura King (Great Ormond Street Hospital, London) to include genes from the Familial rhabdomyosarcoma gene panel (code 290 version 1.4) and the Inherited predisposition to GIST gene panel (code 523, version 0.20). The highest rating for this gene from these two panels was Red, as captured here in this review.Created: 13 Mar 2019, 2:56 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Nevus, Epidermal 162900
Helen Brittain (Genomics England Curator)
One case with associated rhabdomyosarcoma to date. Also a somatic mosaic variant.Created: 21 Dec 2017, 10:34 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Nevus, Epidermal 162900
Details
- Mode of Inheritance
- Other
- Sources
-
- NHS GMS
- Expert Review Red
- Expert Review Red
- Literature
- Phenotypes
-
- Nevus, Epidermal, OMIM:162900
- Rhabdomyosarcoma (disease), MONDO:0005212
- OMIM
- 190070
- Clinvar variants
- Variants in KRAS
- Penetrance
- None
- Publications
- Panels with this gene
-
- Intellectual disability
- DDG2P
- Mosaic skin disorders - deep sequencing
- Pigmentary skin disorders
- Fetal hydrops
- Rare syndromic craniosynostosis or isolated multisuture synostosis
- Familial rhabdomyosarcoma
- RASopathies
- IUGR and IGF abnormalities
- Hereditary neuropathy
- Childhood solid tumours cancer susceptibility
- Primary lymphoedema
- Multiple monogenic benign skin tumours
- Sarcoma cancer susceptibility
- Early onset or syndromic epilepsy
- Cytopenias and congenital anaemias
- COVID-19 research
- Paediatric or syndromic cardiomyopathy
- Fetal anomalies
- Neurological segmental overgrowth
- Hereditary neuropathy or pain disorder
- Segmental overgrowth disorders - Deep sequencing
- Embryonal tumour of possible germline origin
- Sarcoma susceptibility
- Osteogenesis imperfecta
- Monogenic short stature
- Adult solid tumours cancer susceptibility
- Childhood solid tumours
- Sarcoma of possible germline origin
- Primary immunodeficiency or monogenic inflammatory bowel disease
History Filter Activity
Set mode of inheritance
Arina Puzriakova (Genomics England Curator)Mode of inheritance for gene: KRAS was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to Other
Set publications
Arina Puzriakova (Genomics England Curator)Publications for gene: KRAS were set to
Set Phenotypes
Arina Puzriakova (Genomics England Curator)Phenotypes for gene: KRAS were changed from Nevus, Epidermal 162900 to Nevus, Epidermal, OMIM:162900; Rhabdomyosarcoma (disease), MONDO:0005212
Added New Source
Rebecca Foulger (Genomics England curator)Source NHS GMS was added to KRAS.
Created, Added New Source, Set mode of inheritance, Set Phenotypes
Rebecca Foulger (Genomics England curator)gene: KRAS was added gene: KRAS was added to Sarcoma susceptibility. Sources: Expert Review Red Mode of inheritance for gene: KRAS was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: KRAS were set to Nevus, Epidermal 162900