Sarcoma susceptibilityGene: WRN
Comment on list classification: Promoted from Red to Amber, awaiting expert clinical review. This is a Green gene on the Childhood solid tumours cancer susceptibility panel version 1.2 and the Thyroid cancer pertinent cancer susceptibility panel version 1.0 for Werner syndrome. It is a confirmed cancer gene in Gen2Phenotype for Werner syndrome.
Created: 18 Apr 2019, 3:07 p.m.
This gene was requested to be added to this panel by Shazia Mahamdallie (GOSH).
Sources: Expert list
Created: 18 Apr 2019, 2:59 p.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Werner syndrome 277700
Phenotypes for gene: WRN were changed from Werner syndrome 277700 to Werner syndrome, OMIM:277700; Osteosarcoma (disease), MONDO:0009807
Source NHS GMS was added to WRN.
gene: WRN was added gene: WRN was added to Sarcoma susceptibility. Sources: Expert Review Amber Mode of inheritance for gene: WRN was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: WRN were set to 28338660 Phenotypes for gene: WRN were set to Werner syndrome 277700