Sarcoma susceptibility

Gene: FOXO1

Red List (low evidence)

FOXO1 (forkhead box O1)
EnsemblGeneIds (GRCh38): ENSG00000150907
EnsemblGeneIds (GRCh37): ENSG00000150907
OMIM: 136533, Gene2Phenotype
FOXO1 is in 3 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

Red List (low evidence)

This gene was added to this panel after feedback from Laura King (Great Ormond Street Hospital, London) to include genes from the Familial rhabdomyosarcoma gene panel (code 290 version 1.4) and the Inherited predisposition to GIST gene panel (code 523, version 0.20). The highest rating for this gene from these two panels was Red, as captured here in this review.
Created: 13 Mar 2019, 2:56 p.m.

Mode of inheritance
Other - please specifiy in evaluation comments

Phenotypes
Rhabdomyosarcoma, alveolar, 268220

Publications

Helen Brittain (Genomics England Curator)

Red List (low evidence)

Somatic events including gene fusions reported in pathogenesis
Created: 21 Dec 2017, 10:34 a.m.

Mode of inheritance
Other - please specify in evaluation comments

Phenotypes
Rhabdomyosarcoma, alveolar, 268220

Publications

Details

Mode of Inheritance
Other - please specifiy in evaluation comments
Sources
  • NHS GMS
  • Expert Review Red
  • Expert Review Red
  • Radboud University Medical Center, Nijmegen
Phenotypes
  • Rhabdomyosarcoma, alveolar, 268220
OMIM
136533
Clinvar variants
Variants in FOXO1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

1 Aug 2019, Gel status: 1

Added New Source

Rebecca Foulger (Genomics England curator)

Source NHS GMS was added to FOXO1.

23 Jul 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: FOXO1 was added gene: FOXO1 was added to Sarcoma susceptibility. Sources: Expert Review Red Mode of inheritance for gene: FOXO1 was set to Other - please specifiy in evaluation comments Publications for gene: FOXO1 were set to 25768946 Phenotypes for gene: FOXO1 were set to Rhabdomyosarcoma, alveolar, 268220