Sarcoma cancer susceptibilityGene: TNFRSF11A
Gene and evidence provided by Adrienne Flanagan, UCL. Comment from Adrienne on the evidence for this gene: "TNFRSF11A is linked to familial Pagetic bone disease and Pagetic bone disease is associated with sarcoma…although the body of evidence linking TNFRSF11A and osteosarcoma is limited."
Created: 14 May 2018, 3:49 p.m.
Ellen McDonagh: Gene and evidence provided by
This gene has been classified as Red List (Low Evidence).
Mode of inheritance for TNFRSF11A was changed from Unknown to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes for TNFRSF11A were set to Paget disease of bone; Polyostotic osteolytic dysplasia (hereditary expansile); Osteosarcoma
TNFRSF11A was added to Sarcoma pertinent cancer susceptibility panel. Sources: Expert list
TNFRSF11A was created by Ellen McDonagh