Sarcoma cancer susceptibility

Gene: TP53

Green List (high evidence)

TP53 (tumor protein p53)
EnsemblGeneIds (GRCh38): ENSG00000141510
EnsemblGeneIds (GRCh37): ENSG00000141510
OMIM: 191170, Gene2Phenotype
TP53 is in 22 panels

4 reviews

Helen Brittain (Genomics England Curator)

Green List (high evidence)

Causation is clear. Rhabdomyosarcoma commonly associated. Reviewed with Clare Turnbull and Gareth Evans for consensus.
Created: 21 Dec 2017, 10:34 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Li-Fraumeni syndrome, 151623

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Details checked against the Gene List for Reporting Germline Findings in Cancer Patients Version 1.5 document, for renal tumour type.
Created: 26 Jul 2017, 12:16 p.m.

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Adult Glioma; Breast; Sarcoma

Ellen Thomas (Genomics England Curator)

Comment on list classification: Key gene in this phenotype.
Created: 10 May 2016, 9:39 a.m.

History Filter Activity

7 Sep 2018, Gel status: 3

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Ellen McDonagh: Comment on list classification

26 Jul 2017, Gel status: 4

Gene classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

This gene has been classified as Green List (High Evidence).

20 Jul 2017, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

TP53 was added to Sarcomapanel. Sources: Expert list

20 Jul 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

TP53 was created by ellenmcdonagh