Sarcoma cancer susceptibility

Gene: WRN

Amber List (moderate evidence)

WRN (Werner syndrome RecQ like helicase)
EnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 17 panels

1 review

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Promoted from Red to Amber, awaiting expert clinical review. This is a Green gene on the Childhood solid tumours cancer susceptibility panel version 1.2 and the Thyroid cancer pertinent cancer susceptibility panel version 1.0 for Werner syndrome. It is a confirmed cancer gene in Gen2Phenotype for Werner syndrome.
Created: 18 Apr 2019, 3:07 p.m.
This gene was requested to be added to this panel by Shazia Mahamdallie (GOSH).
Sources: Expert list
Created: 18 Apr 2019, 2:59 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Werner syndrome 277700

History Filter Activity

18 Apr 2019, Gel status: 2

Entity classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

Gene: wrn has been classified as Amber List (Moderate Evidence).

18 Apr 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: WRN was added gene: WRN was added to Sarcoma cancer susceptibility. Sources: Expert list Mode of inheritance for gene: WRN was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: WRN were set to Werner syndrome 277700