DNA Repair Genes pertinent cancer susceptibility (Version 1.1)

List	Entity	Reviews	Mode of inheritance	Details
Filter Entities 178 Entitiess
Red List (low evidence)	ALKBH2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Direct reversal of damage Activity: 1-meA dioxygenase Tags
Red List (low evidence)	ALKBH3	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Direct reversal of damage Activity: 1-meA dioxygenase Tags
Red List (low evidence)	APEX1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other BER and strand break joining factors Activity: AP endonuclease Tags
Red List (low evidence)	APEX2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other BER and strand break joining factors Activity: AP endonuclease Tags
Red List (low evidence)	APLF	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other BER and strand break joining factors Activity: Accessory factor for DNA end-joining Tags
Red List (low evidence)	APTX	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Editing and processing nucleases Activity: Processing of DNA single-strand interruptions Tags
Red List (low evidence)	ATM	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Genes defective in diseases associated with sensitivity to DNA damaging agents Activity: ataxia telangiectasia Tags
Red List (low evidence)	ATR	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: ATM- and PI-3K-like essential kinase Tags
Red List (low evidence)	ATRIP	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: ATR-interacting protein Tags
Red List (low evidence)	BLM	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Genes defective in diseases associated with sensitivity to DNA damaging agents Activity: Bloom syndrome helicase Tags
Red List (low evidence)	BRCA1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Accessory factor for transcription and recombination, E3 Ubiquitin ligase Tags
Red List (low evidence)	BRCA2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tolerance and repair of DNA crosslinks and other adducts in DNA: Cooperation with RAD51, essential function Tags
Red List (low evidence)	BRIP1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tolerance and repair of DNA crosslinks and other adducts in DNA: DNA helicase, BRCA1-interacting Tags
Red List (low evidence)	CCNH	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Kinase subunits of TFIIH Tags
Red List (low evidence)	CDK7	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Kinase subunits of TFIIH Tags
Red List (low evidence)	CETN2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Binds DNA distortions Tags
Red List (low evidence)	CHAF1A	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Chromatin Structure and Modification Activity: Chromatin assembly factor Tags
Red List (low evidence)	CHEK1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: Effector kinases Tags
Red List (low evidence)	CHEK2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: Effector kinases Tags
Red List (low evidence)	CLK2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: S-phase check point and biological clock protein Tags
Red List (low evidence)	DCLRE1A	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other identified genes with known or suspected DNA repair function Activity: DNA crosslink repair Tags
Red List (low evidence)	DCLRE1B	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other identified genes with known or suspected DNA repair function Activity: Related to SNM1 Tags
Red List (low evidence)	DCLRE1C	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Non-homologous end-joining Activity: Nuclease Tags
Red List (low evidence)	DDB1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Complex defective in XP group E Tags
Red List (low evidence)	DDB2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Complex defective in XP group E Tags
Red List (low evidence)	DMC1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Rad51 homolog, meiosis Tags
Red List (low evidence)	DUT	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Modulation of nucleotide pools Activity: dUTPase Tags
Red List (low evidence)	EME1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Subunits of structure-specific DNA nuclease Tags
Red List (low evidence)	EME2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Subunits of structure-specific DNA nuclease Tags
Red List (low evidence)	ENDOV	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Editing and processing nucleases Activity: incision 3' of hypoxanthine and uracil in DNA and inosine in RNA Tags
Red List (low evidence)	ERCC1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: 5' incision DNA binding subunit Tags
Red List (low evidence)	ERCC2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: 5' to 3' DNA helicase Tags
Red List (low evidence)	ERCC3	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: 3' to 5' DNA helicase Tags
Red List (low evidence)	ERCC4	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: 5' incision catalytic subunit Tags
Red List (low evidence)	ERCC5	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: 3' incision Tags
Red List (low evidence)	ERCC6	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Cockayne syndrome and UV-Sensitive Syndrome Needed for transcription-coupled NER Tags
Red List (low evidence)	ERCC8	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Cockayne syndrome and UV-Sensitive Syndrome Needed for transcription-coupled NER Tags
Red List (low evidence)	EXO1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Editing and processing nucleases Activity: 5' exonuclease Tags
Red List (low evidence)	FAAP20	1 review	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tolerance and repair of DNA crosslinks and other adducts in DNA: FANCA - associated Tags
Red List (low evidence)	FAAP24	1 review	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tolerance and repair of DNA crosslinks and other adducts in DNA: FAAP24 Tags
Red List (low evidence)	FAN1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Editing and processing nucleases Activity: 5' nuclease interacting with FANCD2 Tags
Red List (low evidence)	FANCA	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tags
Red List (low evidence)	FANCB	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tags
Red List (low evidence)	FANCC	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tags
Red List (low evidence)	FANCD2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tolerance and repair of DNA crosslinks and other adducts in DNA: target for monoubiquitination Tags
Red List (low evidence)	FANCE	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tags
Red List (low evidence)	FANCF	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tags
Red List (low evidence)	FANCG	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tags
Red List (low evidence)	FANCI	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tolerance and repair of DNA crosslinks and other adducts in DNA: target for monoubiquitination Tags
Red List (low evidence)	FANCL	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tolerance and repair of DNA crosslinks and other adducts in DNA: Tags
Red List (low evidence)	FANCM	1 review	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tolerance and repair of DNA crosslinks and other adducts in DNA: helicase/translocase Tags drug-toxicity
Red List (low evidence)	FEN1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Editing and processing nucleases Activity: 5' nuclease Tags
Red List (low evidence)	GEN1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Nuclease cleaving Holliday junctions Tags
Red List (low evidence)	GTF2H1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Core TFIIH subunit p62 Tags
Red List (low evidence)	GTF2H2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Core TFIIH subunit p44 Tags
Red List (low evidence)	GTF2H3	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Core TFIIH subunit p34 Tags
Red List (low evidence)	GTF2H4	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Core TFIIH subunit p52 Tags
Red List (low evidence)	GTF2H5	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Core TFIIH subunit p8 Tags
Red List (low evidence)	H2AFX	1 review	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Chromatin Structure and Modification Activity: Histone, phosphorylated after DNA damage Tags new-gene-name
Red List (low evidence)	HELQ	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other identified genes with known or suspected DNA repair function Activity: DNA helicase Tags
Red List (low evidence)	HLTF	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Ubiquitination and modification Activity: E3 ubiquitin ligase, SWI/SNF related, homolog of S. cerevisiae Rad5 Tags
Red List (low evidence)	HUS1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: subunits of PCNA-like sensor of damaged DNA Tags
Red List (low evidence)	LIG1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: DNA ligase Tags
Red List (low evidence)	LIG3	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other BER and strand break joining factors Activity: DNA Ligase III Tags
Red List (low evidence)	LIG4	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Non-homologous end-joining Activity: Ligase Tags
Red List (low evidence)	MAD2L2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: DNA pol zeta subunit Tags
Red List (low evidence)	MBD4	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Base excision repair (BER) DNA glycosylases, major altered base released:U or T opposite G at CpG sequences Tags
Red List (low evidence)	MDC1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: Mediator of DNA damage checkpoint Tags
Red List (low evidence)	MGMT	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Direct reversal of damage Activity: O6-meG alkyltransferase Tags
Red List (low evidence)	MLH1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Mismatch excision repair (MMR) Activity: MutL homologs, forming heterodimer Tags
Red List (low evidence)	MLH3	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Mismatch excision repair (MMR) Activity: MutL homologs of unknown function Tags
Red List (low evidence)	MMS19	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Iron-sulfur cluster loading and transport Tags
Red List (low evidence)	MNAT1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. Tags
Red List (low evidence)	MPG	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Base excision repair (BER) DNA glycosylases, major altered base released:3-meA, ethenoA, hypoxanthine Tags
Red List (low evidence)	MPLKIP	1 review	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Genes defective in diseases associated with sensitivity to DNA damaging agents Activity: non-photosensitive form of trichothiodystrophy Tags
Red List (low evidence)	MRE11	1 review	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: 3' exonuclease, defective in ATLD (ataxia-telangiectasia-like disorder) Tags
Red List (low evidence)	MSH2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Mismatch excision repair (MMR) Activity: Mismatch (MSH2-MSH6) and loop (MSH2-MSH3) recognition Tags
Red List (low evidence)	MSH3	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Mismatch excision repair (MMR) Activity: Mismatch (MSH2-MSH6) and loop (MSH2-MSH3) recognition Tags
Red List (low evidence)	MSH4	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Mismatch excision repair (MMR) Activity: MutS homologs specialized for meiosis Tags
Red List (low evidence)	MSH5	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Mismatch excision repair (MMR) Activity: MutS homologs specialized for meiosis Tags
Red List (low evidence)	MSH6	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Mismatch excision repair (MMR) Activity: Mismatch (MSH2-MSH6) and loop (MSH2-MSH3) recognition Tags
Red List (low evidence)	MUS81	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Subunits of structure-specific DNA nuclease Tags
Red List (low evidence)	MUTYH	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Base excision repair (BER) DNA glycosylases, major altered base released:A opposite 8-oxoG Tags
Red List (low evidence)	NABP2	1 review	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other identified genes with known or suspected DNA repair function Activity: Single-stranded DNA binding protein Tags
Red List (low evidence)	NBN	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Mutated in Nijmegen breakage syndrome Tags
Red List (low evidence)	NEIL1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Base excision repair (BER) DNA glycosylases, major altered base released:Removes thymine glycol Tags
Red List (low evidence)	NEIL2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Base excision repair (BER) DNA glycosylases, major altered base released:Removes oxidative products of pyrimidines Tags
Red List (low evidence)	NEIL3	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Base excision repair (BER) DNA glycosylases, major altered base released:Removes oxidative products of pyrimidines Tags
Red List (low evidence)	NHEJ1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Non-homologous end-joining Activity: End-joining factor Tags
Red List (low evidence)	NTHL1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Base excision repair (BER) DNA glycosylases, major altered base released:Ring-saturated or fragmented pyrimidines Tags
Red List (low evidence)	NUDT1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Modulation of nucleotide pools Activity: 8-oxoGTPase Tags
Red List (low evidence)	OGG1	1 review	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Base excision repair (BER) DNA glycosylases, major altered base released:8-oxoG opposite C Tags
Red List (low evidence)	PALB2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tolerance and repair of DNA crosslinks and other adducts in DNA: co-localizes with BRCA2 (FANCD1) Tags
Red List (low evidence)	PARP1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA Activity: Protects strand interruptions Tags
Red List (low evidence)	PARP2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA Activity: PARP-like enzyme Tags
Red List (low evidence)	PARP3	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA Activity: PARP-like enzyme Tags
Red List (low evidence)	PCNA	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: Sliding clamp for pol delta and pol epsilon Tags
Red List (low evidence)	PER1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: S-phase check point and biological clock protein Tags
Red List (low evidence)	PMS1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Mismatch excision repair (MMR) Activity: MutL homologs of unknown function Tags
Red List (low evidence)	PMS2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Mismatch excision repair (MMR) Activity: MutL homologs, forming heterodimer Tags
Red List (low evidence)	PMS2P3	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Mismatch excision repair (MMR) Activity: MutL homologs of unknown function Tags
Red List (low evidence)	PNKP	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other BER and strand break joining factors Activity: Converts some DNA breaks to ligatable ends Tags
Red List (low evidence)	POLB	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: BER in nuclear DNA Tags
Red List (low evidence)	POLD1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: NER and MMR Tags
Red List (low evidence)	POLE	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: NER and MMR Tags
Red List (low evidence)	POLG	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: BER in mitochondrial DNA Tags
Red List (low evidence)	POLH	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: xeroderma pigmentosum (XP) variant Tags
Red List (low evidence)	POLI	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: Lesion bypass Tags
Red List (low evidence)	POLK	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: Lesion bypass and NER Tags
Red List (low evidence)	POLL	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: Gap-filling during non-homologous end-joining Tags
Red List (low evidence)	POLM	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: Gap filling during non-homologous end-joining Tags
Red List (low evidence)	POLN	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: DNA crosslink repair? Tags
Red List (low evidence)	POLQ	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: Sensitivity to ionizing radiation Tags
Red List (low evidence)	PRKDC	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Non-homologous end-joining Activity: DNA-dependent protein kinase catalytic subunit Tags
Red List (low evidence)	PRPF19	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other identified genes with known or suspected DNA repair function Activity: DNA crosslink repair binding to SETMAR Tags
Red List (low evidence)	RAD1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: subunits of PCNA-like sensor of damaged DNA Tags
Red List (low evidence)	RAD17	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: RFC-like DNA damage sensor Tags
Red List (low evidence)	RAD18	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Ubiquitination and modification Activity: E3 ubiquitin ligase Tags
Red List (low evidence)	RAD23A	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Substitutes for RAD23B Tags
Red List (low evidence)	RAD23B	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Binds DNA distortions Tags
Red List (low evidence)	RAD50	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: ATPase in complex with MRE11A, NBS1 Tags
Red List (low evidence)	RAD51	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Homologous pairing Tags
Red List (low evidence)	RAD51B	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Rad51 homolog Tags
Red List (low evidence)	RAD51C	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tolerance and repair of DNA crosslinks and other adducts in DNA: Rad51 homolog FANCO Tags
Red List (low evidence)	RAD51D	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Rad51 homolog Tags
Red List (low evidence)	RAD52	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Accessory factors for recombination Tags
Red List (low evidence)	RAD54B	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Accessory factors for recombination Tags
Red List (low evidence)	RAD54L	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Accessory factors for recombination Tags
Red List (low evidence)	RAD9A	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: subunits of PCNA-like sensor of damaged DNA Tags
Red List (low evidence)	RBBP8	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: Promotes DNA end resection Tags
Red List (low evidence)	RDM1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other identified genes with known or suspected DNA repair function Activity: Similar to RAD52 Tags
Red List (low evidence)	RECQL	1 review	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other identified genes with known or suspected DNA repair function Activity: DNA helicase Tags
Red List (low evidence)	RECQL4	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Genes defective in diseases associated with sensitivity to DNA damaging agents Activity: Rothmund-Thompson syndrome Tags
Red List (low evidence)	RECQL5	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other identified genes with known or suspected DNA repair function Activity: DNA helicase Tags
Red List (low evidence)	REV1	1 review	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: dCMP transferase Tags
Red List (low evidence)	REV3L	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: DNA polymerases (catalytic subunits) Activity: DNA pol zeta catalytic subunit, essential function Tags
Red List (low evidence)	RIF1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: suppressor of 5'-end-resection Tags
Red List (low evidence)	RNF168	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Ubiquitination and modification Activity: E3 ubiquitin ligase for DSB repair ATM-like and RIDDLE syndrome Tags
Red List (low evidence)	RNF4	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Ubiquitination and modification Activity: E3 ubiquitin ligase Tags
Red List (low evidence)	RNF8	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Ubiquitination and modification Activity: E3 ubiquitin ligase for DSB repair Tags
Red List (low evidence)	RPA1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Binds DNA in preincision complex Tags
Red List (low evidence)	RPA2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Binds DNA in preincision complex Tags
Red List (low evidence)	RPA3	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Binds DNA in preincision complex Tags
Red List (low evidence)	RPA4	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other identified genes with known or suspected DNA repair function Activity: Similar to RPA2 Tags
Red List (low evidence)	RRM2B	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Modulation of nucleotide pools Activity: p53-inducible ribonucleotide reductase small subunit 2 homolog Tags
Red List (low evidence)	SEM1	1 review	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: BRCA2 associated Tags
Red List (low evidence)	SETMAR	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Chromatin Structure and Modification Activity: DNA damage-associated histone methylase and nuclease Tags
Red List (low evidence)	SHPRH	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Ubiquitination and modification Activity: E3 ubiquitin ligase, SWI/SNF related, homolog of S. cerevisiae Rad5 Tags
Red List (low evidence)	SLX1A	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: subunit of SLX1-SLX4 structure-specific nuclease, two identical tandem genes in the human genome Tags
Red List (low evidence)	SLX1B	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: subunit of SLX1-SLX4 structure-specific nuclease, two identical tandem genes in the human genome Tags
Red List (low evidence)	SLX4	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Fanconi anemia Tolerance and repair of DNA crosslinks and other adducts in DNA: nuclease subunit/scaffold BTBD12 (SLX4) FANCP Tags
Red List (low evidence)	SMUG1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Base excision repair (BER) DNA glycosylases, major altered base released:U Tags
Red List (low evidence)	SPO11	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Editing and processing nucleases Activity: endonuclease Tags
Red List (low evidence)	SPRTN	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Ubiquitination and modification Activity: Reads ubiquitylation Tags
Red List (low evidence)	TDG	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Base excision repair (BER) DNA glycosylases, major altered base released:U, T or ethenoC opposite G Tags
Red List (low evidence)	TDP1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Repair of DNA-topoisomerase crosslinks Activity: Removes 3'-tyrosylphosphate and 3'-phosphoglycolate from DNA human disorder SCAN1 Tags
Red List (low evidence)	TDP2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Repair of DNA-topoisomerase crosslinks Activity: 5'- and 3'-tyrosyl DNA phosphodiesterase Tags
Red List (low evidence)	TOPBP1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: DNA damage checkpoint control Tags
Red List (low evidence)	TP53	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: Regulation of the cell cycle Tags
Red List (low evidence)	TP53BP1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other conserved DNA damage response genes Activity: chromatin-binding checkpoint protein Tags
Red List (low evidence)	TREX1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Editing and processing nucleases Activity: 3' exonuclease Tags
Red List (low evidence)	TREX2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Editing and processing nucleases Activity: 3' exonuclease Tags
Red List (low evidence)	UBE2A	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Ubiquitination and modification Activity: Ubiquitin-conjugating enzyme Tags
Red List (low evidence)	UBE2B	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Ubiquitination and modification Activity: Ubiquitin-conjugating enzyme Tags
Red List (low evidence)	UBE2N	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Ubiquitination and modification Activity: Ubiquitin-conjugating complex Tags
Red List (low evidence)	UBE2V2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Ubiquitination and modification Activity: Ubiquitin-conjugating complex Tags
Red List (low evidence)	UNG	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Base excision repair (BER) DNA glycosylases, major altered base released:U Tags
Red List (low evidence)	UVSSA	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: 4p16.3 Tags
Red List (low evidence)	WRN	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Genes defective in diseases associated with sensitivity to DNA damaging agents Activity: Werner syndrome helicase / 3' - exonuclease Tags
Red List (low evidence)	XAB2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: XAB2 Tags
Red List (low evidence)	XPA	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Binds damaged DNA in preincision complex Tags
Red List (low evidence)	XPC	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Nucleotide excision repair (NER) Activity: Binds DNA distortions Tags
Red List (low evidence)	XRCC1	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Other BER and strand break joining factors Activity: LIG3 accessory factor Tags
Red List (low evidence)	XRCC2	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: DNA break and crosslink repair Tags
Red List (low evidence)	XRCC3	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Homologous recombination Activity: DNA break and crosslink repair Tags
Red List (low evidence)	XRCC4	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Non-homologous end-joining Activity: Ligase accessory factor Tags
Red List (low evidence)	XRCC5	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Non-homologous end-joining Activity: DNA end binding subunit Tags
Red List (low evidence)	XRCC6	0 reviews	Not set	Sources Human DNA Repair Genes Database Phenotypes Class: Non-homologous end-joining Activity: DNA end binding subunit Tags

DNA Repair Genes pertinent cancer susceptibility (Version 1.1)

2 reviewers

178 Entities

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