This Panel is marked as Internal
DNA Repair Genes pertinent cancer susceptibility
Gene: WRN
WRN (Werner syndrome RecQ like helicase)
EnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 18 panels
EnsemblGeneIds (GRCh38): ENSG00000165392
EnsemblGeneIds (GRCh37): ENSG00000165392
OMIM: 604611, Gene2Phenotype
WRN is in 18 panels
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Details
- Sources
-
- Human DNA Repair Genes Database
- Phenotypes
-
- Class: Genes defective in diseases associated with sensitivity to DNA damaging agents
- Activity: Werner syndrome helicase / 3' - exonuclease
- OMIM
- 604611
- Clinvar variants
- Variants in WRN
- Penetrance
- Complete
- Panels with this gene
-
- Sarcoma cancer susceptibility
- Primary ovarian insufficiency
- Insulin resistance (including lipodystrophy)
- Monogenic short stature
- Monogenic diabetes
- Severe insulin resistance and lipodystrophy syndromes
- Bilateral congenital or childhood onset cataracts
- Sarcoma susceptibility
- Osteogenesis imperfecta
- IUGR and IGF abnormalities
- Childhood solid tumours
- Skeletal dysplasia
- Sarcoma of possible germline origin
- Intellectual disability
- Inherited non-medullary thyroid cancer
- Thyroid cancer pertinent cancer susceptibility
- Structural eye disease
- Childhood solid tumours cancer susceptibility
History Filter Activity
7 Sep 2018, Gel status: 1
Panel promoted to version 1.0
Louise Daugherty (Genomics England Curator)Louise Daugherty: added new-gene-name tag. Appr
21 Jun 2017, Gel status: 0
Created
Ellen McDonagh (Genomics England Curator)WRN was created by ellenmcdonagh
21 Jun 2017, Gel status: 0
Added New Source
Ellen McDonagh (Genomics England Curator)WRN was added to DNA Repair Genespanel. Sources: Human DNA Repair Genes Database