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  3. SDHAF4
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Mitochondrial disorders

Gene: SDHAF4

Red List (low evidence)
SDHAF4 (succinate dehydrogenase complex assembly factor 4)
EnsemblGeneIds (GRCh38): ENSG00000154079
EnsemblGeneIds (GRCh37): ENSG00000154079
SDHAF4 is in 3 panels

3 reviews

Arina Puzriakova (Genomics England Curator)

The rating of this gene has been updated from Amber to Red following NHS Genomic Medicine Service approval.
Created: 29 Jul 2022, 1:47 p.m. | Last Modified: 29 Jul 2022, 1:47 p.m.
Panel Version: 2.109
Created: 29 Jul 2022, 1:47 p.m.
Last Modified: 29 Jul 2022, 1:47 p.m.
Panel version: 2.109

Zornitza Stark (Australian Genomics)

Red List (low evidence)

Cannot find evidence for gene-disease association in humans. Only functional assays in mammalian cells and a Drosophila model.
Created: 23 Mar 2020, 1:22 a.m. | Last Modified: 23 Mar 2020, 1:22 a.m.
Panel Version: 2.5

Publications

Created: 23 Mar 2020, 1:22 a.m.
Last Modified: 23 Mar 2020, 1:22 a.m.
Panel version: 2.5

Sarah Leigh (Genomics England Curator)

I don't know

Initial gene list and info collated by Carl Fratter (Oxford University Hospitals NHS Trust) January 2019 on behalf of the GMS Mitochondrial specialist test group.
Created: 23 Jul 2019, 10:13 a.m. | Last Modified: 23 Jul 2019, 10:13 a.m.
Panel Version: 1.412
Created: 23 Jul 2019, 10:13 a.m.
Last Modified: 23 Jul 2019, 10:13 a.m.
Panel version: 1.412

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Red
  • NHS GMS
Phenotypes
  • No OMIM phenotype
Clinvar variants
Variants in SDHAF4
Penetrance
None
Panels with this gene

History Filter Activity

29 Jul 2022, Gel status: 1

Added New Source, Status Update

Arina Puzriakova (Genomics England Curator)

Source Expert Review Red was added to SDHAF4. Rating Changed from Amber List (moderate evidence) to Red List (low evidence)

23 Jul 2019, Gel status: 2

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Sarah Leigh (Genomics England Curator)

gene: SDHAF4 was added gene: SDHAF4 was added to Mitochondrial disorders. Sources: NHS GMS,Expert Review Amber Mode of inheritance for gene: SDHAF4 was set to Unknown Phenotypes for gene: SDHAF4 were set to No OMIM phenotype