Mitochondrial disorders
Gene: DARSAdded new-gene-name tag, new approved HGNC gene symbol for DARS is DARS1Created: 6 Sep 2019, 11:37 a.m. | Last Modified: 6 Sep 2019, 11:37 a.m.
Panel Version: 1.485
Comment on list classification: This gene was demoted from Green to Red, based on the reviews of clinical experts.Created: 19 Jun 2019, 12:37 p.m.
No link to mitochondrial disease & phenotype does not seem particularly similar to a mitochondrial conditionCreated: 19 Jun 2019, 12:26 p.m.
Phenotypes
Hypomyelination with brainstem and spinal cord involvement and leg spasticity, 615281
Red - not considered a primary mitochondrial disorder; DARS encodes the cytoplasmic aspartyl-tRNA synthetaseCreated: 11 Jun 2019, 3:59 p.m.
Phenotypes
Hypomyelination with brainstem and spinal cord involvement and leg spasticity, 615281
Definitely a green gene. DARS2 is a mitochondrial tRNA synthese, but what is the link between DARS and mitochondria?Created: 29 Aug 2018, 5:46 a.m.
Comment on mode of inheritance: Sourced from OMIM and G2P.Created: 26 Feb 2016, 5:31 p.m.
Comment on list classification: Promoted from red to green due to expert review, is also rated green on the intellectual disability panel, and is a confirmed DD gene.Created: 26 Feb 2016, 5:30 p.m.
Tag new-gene-name tag was added to gene: DARS.
Gene: dars has been classified as Red List (Low Evidence).
Mode of inheritance for DARS was changed to BIALLELIC, autosomal or pseudoautosomal
Phenotypes for DARS were set to Hypomyelination with brainstem and spinal cord involvement and leg spasticity
This gene has been classified as Green List (High Evidence).
DARS was added to All recognised syndromes and those with suggestive featurespanel. Sources: Expert