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  3. TTC8
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Severe early-onset obesity

Gene: TTC8

Green List (high evidence)
TTC8 (tetratricopeptide repeat domain 8)
EnsemblGeneIds (GRCh38): ENSG00000165533
EnsemblGeneIds (GRCh37): ENSG00000165533
OMIM: 608132, Gene2Phenotype
TTC8 is in 20 panels

3 reviews

Ismaa Farooqi (University of Cambridge)

Green List (high evidence)

Variants in this GENE are reported as part of current diagnostic practice

Created: 15 Aug 2019, 2:02 p.m.
Last Modified: 15 Aug 2019, 2:02 p.m.
Panel version: 1.22

Ayesha Ahmed (GEL)

Comment on list classification: expert opinion + assoc with BBS8. Evidence in literature - 3 families
Created: 1 Sep 2016, 11:54 a.m.
Created: 1 Sep 2016, 11:54 a.m.

Panel version: 0.100

stephen o'rahilly (university of cambridge)

Green List (high evidence)

Created: 27 Dec 2015, 5:24 p.m.

Panel version: 0.50

History Filter Activity

17 Mar 2021, Gel status: 3

Set Phenotypes

Ivone Leong (Genomics England Curator)

Phenotypes for gene: TTC8 were changed from Obesity; Bardet-Biedl syndrome 8, 615985; Bardet-Biedl syndrome 8 to Obesity; Bardet-Biedl syndrome 8, OMIM:615985

15 Aug 2019, Gel status: 3

Added New Source, Set Phenotypes

Ivone Leong (Genomics England Curator)

Source Expert list was added to TTC8. Added phenotypes Bardet-Biedl syndrome 8, 615985 for gene: TTC8

25 Oct 2016, Gel status: 4

panel promoted to version 1

Ellen McDonagh (Genomics England Curator)

25/Oct/2016: Panel revised according to expert review and additional curation with internal discussion. Ready to be promoted to version 1.

18 Oct 2016, Gel status: 4

Set Phenotypes

Ellen McDonagh (Genomics England Curator)

Phenotypes for TTC8 were set to Obesity;Bardet-Biedl syndrome 8

1 Sep 2016, Gel status: 4

Gene classified by Genomics England curator

Ayesha Ahmed (GEL)

This gene has been classified as Green List (High Evidence).

1 Sep 2016, Gel status: 4

Set Mode of Inheritance

Ayesha Ahmed (GEL)

Mode of inheritance for TTC8 was changed to BIALLELIC, autosomal or pseudoautosomal

1 Sep 2016, Gel status: 4

Gene classified by Genomics England curator

Ayesha Ahmed (GEL)

This gene has been classified as Green List (High Evidence).

18 Aug 2015, Gel status: 1

Added New Source

Eik Haraldsdottir (Genomics England)

TTC8 was added to Significant early-onset obesity +/- other endocrine features and short staturepanel. Sources: Emory Genetics Laboratory