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  3. FZD6
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Fetal hydrops

Gene: FZD6

Amber List (moderate evidence)
FZD6 (frizzled class receptor 6)
EnsemblGeneIds (GRCh38): ENSG00000164930
EnsemblGeneIds (GRCh37): ENSG00000164930
OMIM: 603409, Gene2Phenotype
FZD6 is in 5 panels

2 reviews

Sarah Leigh (Genomics England Curator)

I don't know

FZD6 variants are associated with Nail disorder, nonsyndromic congenital (OMIM:161050). However, three FZD6 variants have been associated with two unrelated cases of fetal hyrdrops (PMID: 33082562;26036949;28425981).
Created: 9 Jul 2024, 1:54 p.m. | Last Modified: 9 Jul 2024, 1:54 p.m.
Panel Version: 1.78

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Created: 9 Jul 2024, 1:54 p.m.
Last Modified: 9 Jul 2024, 1:54 p.m.
Panel version: 1.78

Irina Adamena (Children's Clinical University Hospital)

Green List (high evidence)

Gene with strong evidence for fetal hydrops (PMID: 33082562)
Sources: Literature
Created: 11 Apr 2024, 4:33 p.m.

Mode of inheritance
Unknown

Phenotypes
Nonimmune hydrops fetalis

Publications

Created: 11 Apr 2024, 4:33 p.m.

Panel version: 1.64

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Amber
Phenotypes
  • Nail disorder, nonsyndromic congenital, 1, OMIM:161050
OMIM
603409
Clinvar variants
Variants in FZD6
Penetrance
None
Publications
Panels with this gene

History Filter Activity

9 Jul 2024, Gel status: 2

Entity classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

Gene: fzd6 has been classified as Amber List (Moderate Evidence).

9 Jul 2024, Gel status: 0

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for gene: FZD6 were changed from Nonimmune hydrops fetalis to Nail disorder, nonsyndromic congenital, 1, OMIM:161050

9 Jul 2024, Gel status: 0

Set mode of inheritance

Sarah Leigh (Genomics England Curator)

Mode of inheritance for gene: FZD6 was changed from Unknown to BIALLELIC, autosomal or pseudoautosomal

9 Jul 2024, Gel status: 0

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: FZD6 were set to 33082562; 26036949

9 Jul 2024, Gel status: 0

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: FZD6 were set to 33082562; 26036949

9 Jul 2024, Gel status: 0

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: FZD6 were set to 33082562

9 Jul 2024, Gel status: 0

Set publications

Sarah Leigh (Genomics England Curator)

Publications for gene: FZD6 were set to PMID: 33082562

11 Apr 2024, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Irina Adamena (Children's Clinical University Hospital)

gene: FZD6 was added gene: FZD6 was added to Fetal hydrops. Sources: Literature Mode of inheritance for gene: FZD6 was set to Unknown Publications for gene: FZD6 were set to PMID: 33082562 Phenotypes for gene: FZD6 were set to Nonimmune hydrops fetalis Review for gene: FZD6 was set to GREEN