Fetal hydrops

Gene: KRAS

Green List (high evidence)

KRAS (KRAS proto-oncogene, GTPase)
EnsemblGeneIds (GRCh38): ENSG00000133703
EnsemblGeneIds (GRCh37): ENSG00000133703
OMIM: 190070, Gene2Phenotype
KRAS is in 30 panels

1 review

Rebecca Foulger (Genomics England curator)

Comment on mode of pathogenicity: Gain of function mutations.
Created: 21 Dec 2016, 2:50 p.m.

History Filter Activity

21 Dec 2016, Gel status: 4

panel promoted to version 1

Rebecca Foulger (Genomics England curator)

21 December 2016. External reviews were assessed, and panel was revised according to expert review, internal discussion and additional curation. Following internal discussion, all genes from the V1.14 'RASopathies' panel were added as green EXCLUDING NF1 and SPRED1- a cautious approach was taken because Fetal hydrops is a fetal panel. All relevant genes from the 'Mucopolysaccharideosis, Gaucher, Fabry' V1.0 panel (lysosomal storage disorders) were also added to the Fetal hydrops panel as green together with genes from the literature where there is a reasonable link between the corresponding lysosomal storage disorder (LSD) and Fetal hydrops. All PEX genes from the V1.2 'Peroxisomal disorders' panel were added as green based on a link between peroxisomal biogenesis disorders and Fetal hydrops.

21 Dec 2016, Gel status: 4

Set mode of pathogenicity

Rebecca Foulger (Genomics England curator)

Mode of pathogenicity for KRAS was changed to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments

21 Dec 2016, Gel status: 4

Upload gene information

Rebecca Foulger (Genomics England curator)

KRAS was added to Fetal hydropspanel. Sources: Eligibility statement prior genetic testing

19 Dec 2016, Gel status: 0

Created

Rebecca Foulger (Genomics England curator)

KRAS was created by rfoulger

19 Dec 2016, Gel status: 4

Added New Source

Rebecca Foulger (Genomics England curator)

KRAS was added to Fetal hydropspanel. Sources: Expert Review Green