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  3. TTC26
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Rare multisystem ciliopathy disorders

Gene: TTC26

Green List (high evidence)
TTC26 (tetratricopeptide repeat domain 26)
EnsemblGeneIds (GRCh38): ENSG00000105948
EnsemblGeneIds (GRCh37): ENSG00000105948
OMIM: 617453, Gene2Phenotype
TTC26 is in 7 panels

2 reviews

Ida Ertmanska (Genomics England Curator)

The 'new-gene-symbol' tag has been added as the HGNC approved official gene symbol for TTC26 is IFT56.
Created: 1 May 2026, 2:40 p.m. | Last Modified: 1 May 2026, 2:40 p.m.
Panel Version: 1.182
Created: 1 May 2026, 2:40 p.m.
Last Modified: 1 May 2026, 2:40 p.m.
Panel version: 1.182

Zornitza Stark (Australian Genomics)

Green List (high evidence)

9 families and functional data including zebrafish model.
Sources: Literature
Created: 8 Jul 2021, 8:39 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Ciliopathy Syndrome with Biliary, Renal, Neurological, and Skeletal Manifestations

Publications

Created: 8 Jul 2021, 8:39 a.m.

Panel version: 1.142

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Biliary, renal, neurologic, and skeletal syndrome, OMIM:619534 biliary, renal, neurologic, and skeletal syndrome, MONDO:0859191
Tags
new-gene-name
OMIM
617453
Clinvar variants
Variants in TTC26
Penetrance
None
Publications
Panels with this gene

History Filter Activity

1 May 2026, Gel status: 3

Added Tag

Ida Ertmanska (Genomics England Curator)

Tag new-gene-name tag was added to gene: TTC26.

22 Apr 2026, Gel status: 3

Set Phenotypes

Ida Ertmanska (Genomics England Curator)

Phenotypes for gene: TTC26 were changed from Ciliopathy Syndrome with Biliary, Renal, Neurological, and Skeletal Manifestations to Biliary, renal, neurologic, and skeletal syndrome, OMIM:619534 biliary, renal, neurologic, and skeletal syndrome, MONDO:0859191

22 Apr 2026, Gel status: 3

Entity classified by Genomics England curator

Ida Ertmanska (Genomics England Curator)

Gene: ttc26 has been classified as Green List (High Evidence).

8 Jul 2021, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Zornitza Stark (Australian Genomics)

gene: TTC26 was added gene: TTC26 was added to Rare multisystem ciliopathy disorders. Sources: Literature Mode of inheritance for gene: TTC26 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: TTC26 were set to 34177428; 32617964; 31595528; 24596149; 22718903 Phenotypes for gene: TTC26 were set to Ciliopathy Syndrome with Biliary, Renal, Neurological, and Skeletal Manifestations Review for gene: TTC26 was set to GREEN